{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:40:13Z","timestamp":1773088813994,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Periodontal and cardiovascular diseases share some common underlying mechanisms. Hyperlipidemia is a major risk factor for cardiovascular diseases. This study sought to assess the association of hyperlipidemia and statin consumption with periodontal status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This cross\u2010sectional study was conducted on 150 participants including 50 individuals with normal lipid profile (group C), 50 hyperlipidemic patients without drug therapy (group N), and 50 hyperlipidemic patients on drug therapy for a minimum of 3\u00a0months (group S). Periodontal parameters including plaque index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>), clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>), bleeding on probing (<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>), and pocket depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) were measured for all teeth except for the third molars. Serum levels of total cholesterol (<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LDL<\/jats:styled-content>, and triglycerides (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>s) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean values of <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> were significantly higher in the two hyperlipidemic groups compared with the C group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.005). Also, <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> had significant associations with serum levels of <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>s, <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001); <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> in the group S was significantly lower than that in the other groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hyperlipidemic patients showed higher values of periodontal parameters compared with the statin\u2010treated and control groups. Lower <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> in the group S may indicate the anti\u2010inflammatory effect of statin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12545","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T12:07:14Z","timestamp":1468843634000},"page":"775-780","source":"Crossref","is-referenced-by-count":18,"title":["Association of serum lipid indices and statin consumption with periodontal status"],"prefix":"10.1111","volume":"22","author":[{"given":"F","family":"Sayar","sequence":"first","affiliation":[{"name":"Department of Periodontics Tehran Dental Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Fallah","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Milad Hospital Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Akhondi","sequence":"additional","affiliation":[{"name":"Department of Mathematics South Tehran Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Private Practice Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120366"},{"key":"e_1_2_9_3_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J","year":"1975","journal-title":"Int Dent J"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12131"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.12.1429"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.13-002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01619.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080104"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01644.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100417"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01880.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140561"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.130652"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-013-0481-6"},{"key":"e_1_2_9_16_1","unstructured":"JurkowskiIN(2010).Statins regulate IL\u20101\u03b2 \u2013 induced RANKL and OPG production by human gingival fibroblasts[dissertation].Memphis Tennessee:University of Tennessee. Available at:www.gradworks.umi.com\/14\/75\/1475275.html[accessed on 1 January 2016]."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.5.494"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2230112.x"},{"issue":"1","key":"e_1_2_9_19_1","first-page":"46","article-title":"Lipoprotein apheresis results in plaque stabilization and prevention of cardiovascular events: comments on the prospective pro(a)life study","volume":"10","author":"Klingel R","year":"2015","journal-title":"Clin Res C ardiol"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01758.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12095"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2013.627"},{"key":"e_1_2_9_23_1","first-page":"8","article-title":"Statin use is associated with fewer periodontal lesions: A retrospective study","volume":"15","author":"Lindy O","year":"2008","journal-title":"BMC Oral Health"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027008537.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242005000400009"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.008940"},{"key":"e_1_2_9_27_1","first-page":"47","article-title":"A study on the evaluation of periodontal status in patients with hyperlipidemia","volume":"1","author":"Navkiran KS","year":"2011","journal-title":"J Comp Dent Care"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600503"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090429"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110716"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12042"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110756"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01046.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01331.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01484.x"},{"key":"e_1_2_9_36_1","first-page":"104","article-title":"Association of serum LDL cholesterol level with periodontitis among patients visiting a tertiary\u2010care hospital","volume":"51","author":"Sharma S","year":"2011","journal-title":"JNMA"},{"key":"e_1_2_9_37_1","first-page":"1","article-title":"Simvastatin and periodontal regeneration","volume":"21","author":"Singh SK","year":"2012","journal-title":"J Pharma Biomed Sci"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11.1861"},{"key":"e_1_2_9_39_1","first-page":"808","article-title":"Statins in periodontal regeneration \u2013the current scenario","volume":"4","author":"Suresh S","year":"2012","journal-title":"Indian J Dent Adv"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2009.01263.x"},{"key":"e_1_2_9_41_1","first-page":"47","article-title":"Association between chronic periodontitis and serum lipid levels","volume":"48","author":"Taleghani F","year":"2010","journal-title":"Acta Medica Iranica"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1970.41.1.41"},{"key":"e_1_2_9_43_1","first-page":"96","article-title":"The relationship between blood serum lipids and periodontal condition","volume":"8","author":"Valentaviciene G","year":"2006","journal-title":"Stomatologija"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12545","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T08:47:56Z","timestamp":1695718076000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,11]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/odi.12545"],"URL":"https:\/\/doi.org\/10.1111\/odi.12545","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,11]]}}}