{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:39:23Z","timestamp":1782743963710,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T00:00:00Z","timestamp":1471219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Angiotensin\u2010converting enzyme (<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>) downregulates the activity of bradykinin, a potent proinflammatory and immunostimulatory peptide liberated from an internal portion of kininogens. Here, we asked whether periodontitis is worsened in patients under antihypertensive treatment with <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Periodontal parameters were recorded from 30 individuals taking <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> inhibitors (case) and 35 taking a non\u2010<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> inhibitor medication (control). Data were analyzed by nonparametric and parametric statistical tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most sociodemographic figures were similar in both groups. However, family income was statistically higher in the control group, and the percentage of sites with visible plaque (PL) was statistically higher in the case group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005, respectively). The prevalence of individuals with chronic periodontitis varied from 31.5% in the control group to 63.4% in the case group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Patients in the case group presented a 3.2\u2010fold higher risk of having sites with pocket depth \u22655\u00a0mm and a 2.9\u2010fold higher risk of having sites with clinical attachment loss \u22655\u00a0mm in comparison with those in the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001, respectively; adjusted for family income and visible PL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Angiotensin\u2010converting enzyme inhibitors may increase the prevalence and extent of chronic periodontitis in Brazilian patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12551","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T11:16:43Z","timestamp":1471259803000},"page":"791-796","source":"Crossref","is-referenced-by-count":19,"title":["Effect of antihypertensive therapy with angiotensin\u2010converting enzyme inhibitors on chronic periodontitis: a case\u2013control study"],"prefix":"10.1111","volume":"22","author":[{"given":"M","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Division of Graduate Periodontics School of Dentistry Federal University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Barbirato","sequence":"additional","affiliation":[{"name":"Division of Graduate Periodontics School of Dentistry Federal University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RR","family":"Luiz","sequence":"additional","affiliation":[{"name":"Institute for Collective Health Studies Federal University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Scharfstein","sequence":"additional","affiliation":[{"name":"Carlos Chagas Filho Institute of Biophysics Federal University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GF","family":"Salles","sequence":"additional","affiliation":[{"name":"School of Medicine Federal University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EJ","family":"Feres\u2010Filho","sequence":"additional","affiliation":[{"name":"Division of Graduate Periodontics School of Dentistry Federal University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,15]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J","year":"1975","journal-title":"Int Dent J"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.11.5349"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2010.01314.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00416.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150295"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000136759.43571.7f"},{"key":"e_1_2_8_8_1","first-page":"145","article-title":"Genetic manipulation and genetic variation of the kallikrein\u2010kinin system: impact on cardiovascular and renal diseases","volume":"69","author":"Girolami JP","year":"2014","journal-title":"Prog Drug Res"},{"key":"e_1_2_8_9_1","first-page":"307","volume-title":"Kinins","author":"Herwald H","year":"2011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12392"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-008-0787-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00136.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.50.33224"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350500377859"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512465435"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.1.2"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61766-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000431740.32696.cc"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900895"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.03202.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060264"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280103.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600503"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00966-10"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.04.002"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.2.1199-1201.2001"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1999.tb00165.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500302"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000378"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00127.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753944712444866"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12551","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T08:47:39Z","timestamp":1695718059000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,15]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/odi.12551"],"URL":"https:\/\/doi.org\/10.1111\/odi.12551","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,15]]}}}