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The aim of our study was to analyze possible associations between seven single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in <jats:italic>interleukin\u201017A<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017<\/jats:italic>), <jats:italic>osteopontin<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">SPP<\/jats:styled-content>1<\/jats:italic>), <jats:italic>purinoreceptor P2X7<\/jats:italic> (<jats:italic>P2<jats:styled-content style=\"fixed-case\">RX<\/jats:styled-content>7<\/jats:italic>), and <jats:italic>tumor necrosis factor receptor superfamily member 11B<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">TNFRSF<\/jats:styled-content>11B<\/jats:italic>) genes and <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> in children after orthodontic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>This case\u2013control study comprised 99 orthodontically treated patients (69 controls and 30 subjects with <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>). Genotype determinations of rs2275913, rs11730582, rs9138, rs208294, rs1718119, rs3102735, and rs2073618 were based on polymerase chain reaction using 5\u2032 nuclease TaqMan<jats:sup>\u00ae<\/jats:sup> assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>While no significant differences were observed in allele or genotype frequencies of all seven studied <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s, specific haplotype of <jats:italic>P2<jats:styled-content style=\"fixed-case\">RX<\/jats:styled-content>7<\/jats:italic> (rs208294 and rs1718119) modified the risk of <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> development (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In addition, the length of treatment with a fixed orthodontic appliance positively correlated with the presence of <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the effect of individual <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s studied on the <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content> development was not confirmed in the Czech population, complex analysis suggested that variability in the <jats:italic>P2<jats:styled-content style=\"fixed-case\">RX<\/jats:styled-content>7<\/jats:italic> gene and the length of orthodontic treatment may be important factors contributing to the etiopathogenesis of postorthodontic <jats:styled-content style=\"fixed-case\">EARR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12564","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T08:33:47Z","timestamp":1470386027000},"page":"29-35","source":"Crossref","is-referenced-by-count":30,"title":["Genetic determinants and postorthodontic external apical root resorption in Czech children"],"prefix":"10.1111","volume":"23","author":[{"given":"P","family":"Borilova Linhartova","sequence":"first","affiliation":[{"name":"Clinic of Stomatology Institutions Shared with St. Anne's Faculty Hospital Faculty of Medicine Masaryk University Brno Czech Republic"},{"name":"Department of Pathophysiology Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Cernochova","sequence":"additional","affiliation":[{"name":"Clinic of Stomatology Institutions Shared with St. Anne's Faculty Hospital Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kastovsky","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Vrankova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sirotkova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Izakovicova Holla","sequence":"additional","affiliation":[{"name":"Clinic of Stomatology Institutions Shared with St. Anne's Faculty Hospital Faculty of Medicine Masaryk University Brno Czech Republic"},{"name":"Department of Pathophysiology Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2007.04.035"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2003.42"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200506"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2007.10.051"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12384"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2979846"},{"key":"e_1_2_7_8_1","first-page":"175","article-title":"Orthodontically induced inflammatory root resorption. 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