{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:55:27Z","timestamp":1787496927094,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T00:00:00Z","timestamp":1473897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This randomized, double\u2010blind, placebo\u2010controlled crossover study assessed the efficacy of topical tocopherol acetate compared with placebo in easing oral discomfort in patients with reticular oral lichen planus (\n                      <jats:styled-content style=\"fixed-case\">ROLP<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010four patients with clinically diagnosed and histologically confirmed\n                      <jats:styled-content style=\"fixed-case\">ROLP<\/jats:styled-content>\n                      were randomly assigned to two groups, which received first one of two treatments (treatment 1 or 2) for a month, then the other (treatment 2 or 1) for another month, with a two\u2010week washout between them. One treatment contained tocopherol acetate and the other only liquid paraffin. The primary outcome was less discomfort, measured on a visual analog scale (\n                      <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>\n                      ). Secondary outcomes were as follows: length of striae measured and photographed at each follow\u2010up; surface area of lesions; and a modified Thongprasom score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No statistically significant differences emerged between the two treatments (1\n                      <jats:italic>vs<\/jats:italic>\n                      2) in terms of\n                      <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>\n                      scores (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &gt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.05; 0.8624) or length of striae (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.0883). Significant differences were seen for surface area of lesions (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.05,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.0045) and modified Thongprasom scores (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.0052).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The two treatments differed only in terms of the surface area of the lesions and Thongprasom scores, not in\n                      <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>\n                      scores for discomfort or the length of patients\u2019 striae. Topical tocopherol proved effective in the treatment of\n                      <jats:styled-content style=\"fixed-case\">ROLP<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.12573","type":"journal-article","created":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T10:18:40Z","timestamp":1471688320000},"page":"62-68","source":"Crossref","is-referenced-by-count":16,"title":["Topical tocopherol for treatment of reticular oral lichen planus: a randomized, double\u2010blind, crossover study"],"prefix":"10.1111","volume":"23","author":[{"given":"C","family":"Bacci","sequence":"first","affiliation":[{"name":"Department of Neurosciences Section\u00a0of Clinical Dentistry University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Vanzo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Section\u00a0of Clinical Dentistry University 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