{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:34:51Z","timestamp":1789220091310,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K11287"],"award-info":[{"award-number":["15K11287"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24792347"],"award-info":[{"award-number":["24792347"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We analyzed the diagnostic performance of the <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> imaging findings of the parotid, submandibular, and sublingual glands to discriminate between patients with and without Sj\u00f6gren's syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the correlation between the <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> imaging and histopathological findings obtained from 69 patients with clinically suspected Sj\u00f6gren's syndrome. We evaluated the heterogeneous signal intensity distribution on T1\u2010 and T2\u2010weighted images, the multiple high\u2010signal\u2010intensity spots on <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> sialograms, and the volume of the parotid, submandibular, and sublingual salivary glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The multiple high\u2010signal\u2010intensity spots in the parotid gland showed the highest sensitivity and diagnostic accuracy (82% and 83%, respectively). In addition, the multiple high\u2010signal\u2010intensity spots and the heterogeneous signal intensity distribution in the submandibular gland showed high specificity (100% and 88%, respectively). The volume of the submandibular gland, but not that of the parotid or sublingual gland, was smaller in patients with Sj\u00f6gren's syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of multiple high\u2010signal\u2010intensity spots on an <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> sialogram in the parotid gland should be considered the best diagnostic indicator for Sj\u00f6gren's syndrome. The presence of spots, heterogeneity, and the change to smaller volumes in the submandibular gland were also helpful because of their high specificity, particularly in advanced cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12577","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T18:59:43Z","timestamp":1472669983000},"page":"84-90","source":"Crossref","is-referenced-by-count":35,"title":["Diagnostic performance of <scp>MR<\/scp> imaging of three major salivary glands for Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"23","author":[{"given":"I","family":"Kojima","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Iikubo","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kumamoto","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Muroi","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Satoh\u2010Kuriwada","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Graduate School of Dentistry Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-012-2024-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2000.280108.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790090301"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1996.tb00868.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270205"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-004-0338-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(74)90417-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.166.6.8633469"},{"key":"e_1_2_8_10_1","first-page":"951","article-title":"Premature fat deposition in the salivary glands associated with Sj\u00f6gren's syndrome: MR and CT evidence","volume":"18","author":"Izumi M","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11282-011-0062-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780281008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.482"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01215.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)45:6<512::AID-ART376>3.0.CO;2-R"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh187"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.209.3.9844659"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2005.09.001"},{"key":"e_1_2_8_19_1","first-page":"575","article-title":"Secretory sialography in diseases of the major salivary glands","volume":"77","author":"Rubin P","year":"1957","journal-title":"AJR Am J Roentgenol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.dmfr.4600632"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21591"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.4.499"},{"key":"e_1_2_8_23_1","first-page":"33","volume-title":"Dry mouth: the malevolent symptom: a clinical guide","author":"Sreebny LM","year":"2010"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.172.3.10063867"},{"key":"e_1_2_8_25_1","first-page":"1207","article-title":"MR microscopy of the parotid glands in patients with Sj\u04e7gren's syndrome: quantitative MR diagnostic criteria","volume":"26","author":"Takagi Y","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_8_26_1","first-page":"1199","article-title":"MR sialography in patients with Sj\u04e7gren syndrome","volume":"19","author":"Tonami H","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200103000-00020"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00619951"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12577","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:20:44Z","timestamp":1695489644000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,26]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/odi.12577"],"URL":"https:\/\/doi.org\/10.1111\/odi.12577","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,26]]}}}