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Although the number of patients with secondary immunodeficiencies (<jats:styled-content style=\"fixed-case\">SID<\/jats:styled-content>s) greatly exceeds those with primary immunodeficiencies (<jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content>s), the prevalence of both appears to be on the rise probably because of scientific breakthroughs that facilitate earlier and more accurate diagnosis. Primary immunodeficiencies in adults are not as rare as once thought. Globally, the main causes of secondary immunodeficiency are <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection and nutritional insufficiencies. Persons with acquired immune disorders such as <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> caused by the human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>) are now living long and fulfilling lives as a result of highly active antiretroviral therapy (<jats:styled-content style=\"fixed-case\">HAART<\/jats:styled-content>). Irrespective of whether the patient's immune\u2010deficient state is a consequence of a genetic defect or is secondary in nature, dental and medical practitioners must be aware of the constant potential for infections and\/or expressions of autoimmunity in these individuals. The purpose of this review was to study the most common conditions resulting from primary and secondary immunodeficiency states, how they are classified, and the detrimental manifestations of these disorders on the periodontal and oral tissues.<\/jats:p>","DOI":"10.1111\/odi.12584","type":"journal-article","created":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T06:48:46Z","timestamp":1473922126000},"page":"866-888","source":"Crossref","is-referenced-by-count":44,"title":["Periodontal and other oral manifestations of immunodeficiency diseases"],"prefix":"10.1111","volume":"23","author":[{"given":"ME","family":"Peacock","sequence":"first","affiliation":[{"name":"Department of Periodontics The Dental College of Georgia at Augusta University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4721-4722","authenticated-orcid":false,"given":"RM","family":"Arce","sequence":"additional","affiliation":[{"name":"Department of 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