{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:56:08Z","timestamp":1783371368108,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","award":["028\/2014"],"award-info":[{"award-number":["028\/2014"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","award":["070\/2014"],"award-info":[{"award-number":["070\/2014"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to evaluate three histologic grading methods for squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) of the lip, the conventional three\u2010grade model proposed by the World Health Organization, tumor budding and depth of invasion (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) model, and histologic risk assessment (<jats:styled-content style=\"fixed-case\">HRA<\/jats:styled-content>) model, and to correlate them with prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fifty\u2010three patients with lip <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 65\u00a0years, 69.8% of the participants were men, and 66.0% of the patients had early\u2010stage tumors. Using the <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> and conventional three\u2010grade methods, 52.8% and 64.2% of the cases were graded as low risk, respectively. The <jats:styled-content style=\"fixed-case\">HRA<\/jats:styled-content> model graded 54.7% of the cases as medium risk. In the <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> model, the higher histologic grade was associated with worse prognosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.045). Overall survival at 5\u00a0years was 87.8%. Tumor size (T3\u00a0+\u00a0T4) and lymph node involvement (N+) were associated with reduced overall survival and recurrence\u2010free survival (<jats:styled-content style=\"fixed-case\">RFS<\/jats:styled-content>) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002 and 0.005; 0.007 and 0.01, respectively). Surgical treatment combined with radiotherapy was associated with lower <jats:styled-content style=\"fixed-case\">RFS<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010grade lip <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> in advanced stages is associated with a poor prognosis. The <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> model is a simple and effective tool for the prognostic evaluation of lip <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12586","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T08:12:52Z","timestamp":1474877572000},"page":"120-125","source":"Crossref","is-referenced-by-count":29,"title":["Comparative analysis of three histologic grading methods for squamous cell carcinoma of the lip"],"prefix":"10.1111","volume":"23","author":[{"given":"L","family":"Strieder","sequence":"first","affiliation":[{"name":"Department of Bioscience and Oral Diagnosis Institute of Science and Technology UNESP \u2010 Univ. Estadual Paulista S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9016-2668","authenticated-orcid":false,"given":"CM","family":"Coutinho\u2010Camillo","sequence":"additional","affiliation":[{"name":"International Research Center A.C. Camargo Cancer Center S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Oral Diagnosis Institute of Science and Technology UNESP \u2010 Univ. Estadual Paulista S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DE","family":"da Cruz Perez","sequence":"additional","affiliation":[{"name":"Department of Clinical and Preventive Dentistry Federal University of Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LP","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Otorhinolaryngology A.C. Camargo Cancer Center S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Kaminagakura","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Oral Diagnosis Institute of Science and Technology UNESP \u2010 Univ. 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