{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:05:50Z","timestamp":1789203950964,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dutch Organization for Scientific Research","award":["021.001.050"],"award-info":[{"award-number":["021.001.050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Bisphosphonates are widely used to treat bone diseases such as osteoporosis. However, they may cause osteonecrosis of the jaw. Here, we investigated whether\n                      <jats:italic>in\u00a0vivo<\/jats:italic>\n                      exposure to bisphosphonates has a different effect on long bone and jaw osteoclasts, and on the turnover of these different bones.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Zoledronic acid (0.5\u00a0mg\u00a0kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      weekly) was administered intraperitoneally to 3\u2010month\u2010old female mice for up to 6\u00a0months. The effects on the number of osteoclasts, bone mineralization and bone formation were measured in the long bones and in the jaw.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Long\u2010term treatment with zoledronic acid reduced the number of jaw bone marrow cells, without affecting the number of long bone marrow cells. Zoledronic acid treatment did not affect the number of osteoclasts\n                      <jats:italic>in\u00a0vivo<\/jats:italic>\n                      . Yet, the bisphosphonate increased bone volume and mineral density of both long bone and jaw. Interestingly, 6\u00a0months of treatment suppressed bone formation in the long bones without affecting the jaw. Unexpectedly, we showed that bisphosphonates can cause molar root resorption, mediated by\n                      <jats:italic>active<\/jats:italic>\n                      osteoclasts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings provide more insight into bone\u2010site\u2010specific effects of bisphosphonates and into the aetiology of osteonecrosis of the jaw. We demonstrated that bisphosphonates can stimulate osteoclast activity at the molar roots.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.12587","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T15:59:18Z","timestamp":1476287958000},"page":"126-133","source":"Crossref","is-referenced-by-count":23,"title":["Bone\u2010site\u2010specific responses to zoledronic acid"],"prefix":"10.1111","volume":"23","author":[{"given":"JAF","family":"Vermeer","sequence":"first","affiliation":[{"name":"Department of Oral Cell Biology &amp; Functional Anatomy Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and VU University Amsterdam MOVE Research Institute Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GAP","family":"Renders","sequence":"additional","affiliation":[{"name":"Department of Oral Cell Biology &amp; Functional Anatomy Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and VU University Amsterdam MOVE Research Institute Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"van Duin","sequence":"additional","affiliation":[{"name":"Department of Oral Cell Biology &amp; 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