{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:01:19Z","timestamp":1789513279540,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Orsz\u00e1gos Tudom\u00e1nyos Kutat\u00e1si Alapprogramok","doi-asserted-by":"publisher","award":["114458"],"award-info":[{"award-number":["114458"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) is a chronic inflammatory disease of unknown etiology with antigen\u2010specific and non\u2010specific mechanisms. Transient receptor potential ankyrin 1 (<jats:styled-content style=\"fixed-case\">TRPA<\/jats:styled-content>1) is a non\u2010selective cation channel activated by noxious stimuli such as oxidative stress products evoking pain and release of proinflammatory mediators from sensory nerve endings culminating in neurogenic inflammation. Extraneuronal <jats:styled-content style=\"fixed-case\">TRPA<\/jats:styled-content>1s, for example, on immune cells possess yet unknown functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>We studied the buccal <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression (<jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content>) and protein localization (immunohistochemistry) of <jats:styled-content style=\"fixed-case\">TRPA<\/jats:styled-content>1 receptors and key <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> mediator transcripts in oral mucosa samples of healthy volunteers (<jats:italic>n<\/jats:italic>\u00a0=\u00a09), <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a043), and <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>\u2010like hyperkeratotic patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We measured 27.7\u2010 and 25.5\u2010fold <jats:styled-content style=\"fixed-case\">TRPA<\/jats:styled-content>1 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> increase in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>\u2010like hyperkeratotic patients compared to healthy controls. <jats:styled-content style=\"fixed-case\">TRPA<\/jats:styled-content>1 transcripts elevated 2.4\u2010fold in hypertensive <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> but not in hyperkeratotic patients compared to counterparts, reduced by 1.6\u2010fold by angiotensin\u2010convertase inhibitor intake. <jats:styled-content style=\"fixed-case\">TRPA<\/jats:styled-content>1 messenger <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> was more coexpressed with transcripts of tumor necrosis factor <jats:italic>\u03b1<\/jats:italic> than with interferon <jats:italic>\u03b3<\/jats:italic>. Keratinocytes, macrophages but not T cells expressed <jats:styled-content style=\"fixed-case\">TRPA<\/jats:styled-content>1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We provided evidence for the extraneuronal presence and upregulation of the proinflammatory <jats:styled-content style=\"fixed-case\">TRPA<\/jats:styled-content>1 receptor in buccal samples of patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. This may implicate the ion channel in the pathomechanism of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12593","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T06:44:30Z","timestamp":1476341070000},"page":"189-198","source":"Crossref","is-referenced-by-count":21,"title":["<scp>TRPA<\/scp>1 receptor is upregulated in human oral lichen planus"],"prefix":"10.1111","volume":"23","author":[{"given":"J","family":"Kun","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy University of P\u00e9cs Medical School P\u00e9cs Hungary"},{"name":"Molecular Pharmacology Group Szent\u00e1gothai Research Center University of Pecs P\u00e9cs Hungary"},{"name":"MTA\u2010PTE NAP B Chronic Pain Research Group University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Perkecz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy University of P\u00e9cs Medical School P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Knie","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Oral and Maxillofacial Surgery University of P\u00e9cs Medical School P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"G","family":"S\u00e9t\u00e1l\u00f3","sequence":"additional","affiliation":[{"name":"Department of Medical Biology University of P\u00e9cs Medical School P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Torn\u00f3czki","sequence":"additional","affiliation":[{"name":"Oral Pathology Unit Department of Pathology University of P\u00e9cs Medical School 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