{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:23:32Z","timestamp":1791015812899,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to determine the histopathologic findings in actinic cheilitis (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>) and lip squamous cell carcinomas (<jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content>) diagnosed at Federal University of Santa Catarina in order to attempt to predict the evolution from <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content> based on the comparison of two dysplasia classification systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Histopathologic features were evaluated according to the World Health Organization classification of dysplasia and binary system of classification. Also, in <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content>, pattern, stage of invasion, and degree of keratinization were evaluated. A total of 58 cases of <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> and 70 cases of <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content> were studied, and data correlation was performed using statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The presence of dyskeratosis and keratin pearls was found to be strongly associated with severe dysplasia and could represent higher proximity between the severe dysplasia in <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content>. Also, changes related to the nuclei, such as hyperchromasia, nuclear pleomorphism, anisonucleosis, increase in the number and size of nucleoli, increased number of mitoses, and atypical mitoses, indicate progression in dysplasia spectrum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Knowledge of clinical and histological features of <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content> leads to better understanding of factors possibly associated with malignant transformation of epithelial dysplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12597","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T14:56:39Z","timestamp":1476888999000},"page":"219-224","source":"Crossref","is-referenced-by-count":21,"title":["Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems"],"prefix":"10.1111","volume":"23","author":[{"given":"SFM","family":"Pilati","sequence":"first","affiliation":[{"name":"Odontology Health Sciences Center Vale do Itaja\u00ed University Itaja\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BC","family":"Bianco","sequence":"additional","affiliation":[{"name":"Odontology Health Sciences Center Vale do Itaja\u00ed University Itaja\u00ed Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DSC","family":"Vieira","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Service Department of Pathology Federal University of Santa Catarina Florianopolis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Modolo","sequence":"additional","affiliation":[{"name":"Oral Pathology Laboratory Department of Pathology Federal University of Santa Catarina Florianopolis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.33784"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.12.024"},{"key":"e_1_2_7_4_1","unstructured":"BarnesL EvesonJW ReichartP SidranskyD(2005).Tumours of the oral cavity and Oropharynx in: WHO Classification: Head and Neck Tumours.IARC Press:Lyon pp.170\u2013183."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12484"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841215)54:12<2995::AID-CNCR2820541230>3.0.CO;2-R"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00668.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0964-1955(96)00055-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0303-6987.2002.028.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2113"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-010-0169-z"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(99)70115-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.12.014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.03.009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/00007611-200007000-00001","article-title":"Actinic keratosis is squamous cell carcinoma","volume":"93","author":"Lober BA","year":"2000","journal-title":"South Med J"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(05)80226-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2004.01004.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2004.00299.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00440.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12485"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00606.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64720-7"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1985.tb00549.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1285"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.016"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(200107)194:3<294::AID-PATH911>3.0.CO;2-Q"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00584.x"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12597","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T09:32:41Z","timestamp":1696152761000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,28]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/odi.12597"],"URL":"https:\/\/doi.org\/10.1111\/odi.12597","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,28]]}}}