{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:14:12Z","timestamp":1767597252664,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> aneuploidy has been reported to be a predictor of poor prognosis in both premalignant and malignant lesions. In oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>), this hypothesis remains to be proved. This study aimed to determine the rate of occurrence of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> aneuploidy in patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> by high\u2010resolution <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> were consecutively enrolled. Tissue samples were subdivided for formalin fixation and routine histological assessment and for immediate storage at \u221220\u00b0C for later <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> ploidy analysis, which was performed by <jats:styled-content style=\"fixed-case\">DAPI<\/jats:styled-content> staining of the extracted nuclei and excitation with a <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> lamp. The <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> aneuploid sublines were characterized by the <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> Index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> aneuploid status was observed in two of 77 patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> (2.6%). When considering the clinical aspect of the <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> lesions, both <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> aneuploid cases had a reticular clinical aspect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> aneuploidy is an uncommon event in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and less frequent compared to other non\u2010dysplastic and non\u2010<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> oral potentially malignant disorders. The extremely low rate of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> aneuploidy could represent an occasional finding or reflect the low rate of malignant transformation observed in patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> even if the real prognostic value of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> ploidy analysis in patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> remains to be confirmed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12605","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T02:48:45Z","timestamp":1482634125000},"page":"318-323","source":"Crossref","is-referenced-by-count":8,"title":["High\u2010resolution <scp>DNA<\/scp> content analysis of microbiopsy samples in oral lichen planus"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-1203","authenticated-orcid":false,"given":"M","family":"Pentenero","sequence":"first","affiliation":[{"name":"Department of Oncology Oral Medicine and Oral Oncology Unit University of Turin Orbassano (TO) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Monticone","sequence":"additional","affiliation":[{"name":"IRCCS AOU San Martino \u2013IST Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Oncology Oral Medicine and Oral Oncology Unit University of Turin Orbassano (TO) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Aiello","sequence":"additional","affiliation":[{"name":"IRCCS AOU San Martino \u2013IST Genova 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