{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:02:45Z","timestamp":1784739765543,"version":"3.55.0"},"reference-count":63,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>In this review, we will describe the immunopathogies of immune reconstitution inflammatory syndrome, <jats:styled-content style=\"fixed-case\">IRIS<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">IRIS<\/jats:styled-content> occurs in a small subset of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patient, initiating combination antiretroviral therapy (<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>), where immune reconstitution becomes dysregulated, resulting in an overly robust antigen\u2010specific inflammatory reaction. We will discuss <jats:styled-content style=\"fixed-case\">IRIS<\/jats:styled-content> in terms of the associated coinfections: mycobacteria, cryptococci, and viruses.<\/jats:p>","DOI":"10.1111\/odi.12606","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T02:46:45Z","timestamp":1482634005000},"page":"822-827","source":"Crossref","is-referenced-by-count":9,"title":["Immune reconstitution inflammatory syndrome in <scp>HIV<\/scp> infection: taking the bad with the good"],"prefix":"10.1111","volume":"23","author":[{"given":"C\u2010S","family":"Wong","sequence":"first","affiliation":[{"name":"HIV Pathogenesis Section Laboratory of Immunoregulation NIAID\/NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ES","family":"Richards","sequence":"additional","affiliation":[{"name":"HIV Pathogenesis Section Laboratory of Immunoregulation NIAID\/NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Pei","sequence":"additional","affiliation":[{"name":"HIV Pathogenesis Section Laboratory of Immunoregulation NIAID\/NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Sereti","sequence":"additional","affiliation":[{"name":"HIV Pathogenesis Section Laboratory of Immunoregulation NIAID\/NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014181"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014536879"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122587"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit033"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004433"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-285080"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-9-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-286336"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2712"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301004"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-013-0222-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1013911"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312884"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804020"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.14.597"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.019224"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.5.1153"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-016-0051-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505043321802"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-014-0213-0"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/597276"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00703-3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1258\/0956462054308404"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061287"},{"key":"e_1_2_8_27_1","first-page":"798","article-title":"Herpes\u2010like DNA sequences, AIDS\u2010related tumors, and Castleman's disease","volume":"333","author":"Dupin N","year":"1995","journal-title":"N Engl J Med"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545689"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-313"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/595006"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199211000-00009"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv135"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70170-5"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1013607"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ841"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004754"},{"key":"e_1_2_8_37_1","first-page":"1599","article-title":"Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor\u20103","volume":"58","author":"Jussila L","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509213331211"},{"key":"e_1_2_8_39_1","first-page":"636","article-title":"Valganciclovir therapy for immune recovery uveitis complicated by macular edema","volume":"137","author":"Kosobucki BR","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(03)00042-X"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70140-7"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.02976.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-380840"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31825b5e06"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70184-1"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833dfc68"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201201-0094OC"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.12.4031.412a37_4031_4033"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000224"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70733-9"},{"key":"e_1_2_8_51_1","first-page":"4044","article-title":"Reactivation and persistence of human Herpesvirus\u20108 infection in B cells and monocytes by Th\u20101 cytokines increased in Kaposi's Sarcoma","volume":"93","author":"Monini P","year":"1999","journal-title":"Blood"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70026-8"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063541"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.1.9712001"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.02.035"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-377523"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200602000-00007"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e32833ed774"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-168"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000343510.08643.74"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/971417"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402105"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ995"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70361-4"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12606","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:13:59Z","timestamp":1695503639000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,23]]},"references-count":63,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/odi.12606"],"URL":"https:\/\/doi.org\/10.1111\/odi.12606","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,23]]}}}