{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:35:34Z","timestamp":1784543734572,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T00:00:00Z","timestamp":1486512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The amalgam\u2010associated oral lichenoid lesion (<jats:styled-content style=\"fixed-case\">AAOLL<\/jats:styled-content>) shows clinical and histopathological features similar to oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>). Molecular researches to improve knowledge of pathogenesis and clinical behavior of <jats:styled-content style=\"fixed-case\">AAOLL<\/jats:styled-content> are still scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We investigated for the first time the use of loss of heterozygosity (<jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content>) as a molecular approach for genetic characterization of <jats:styled-content style=\"fixed-case\">AAOLL<\/jats:styled-content> in comparison with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and evaluated the cell proliferation index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The sample comprised nine <jats:styled-content style=\"fixed-case\">AAOLL<\/jats:styled-content>s, 10 <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>s, and eight <jats:styled-content style=\"fixed-case\">NOM<\/jats:styled-content>s matched by patients\u2019 gender and age. <jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content> was assessed using polymorphic microsatellite markers at chromosomes 9p (D9S157, D9S162, D9S171), 11q (D11S1369), and 17p (<jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>53, <jats:styled-content style=\"fixed-case\">AFM<\/jats:styled-content>238<jats:styled-content style=\"fixed-case\">WF<\/jats:styled-content>2). Cell proliferation was assessed by immunohistochemical expression of Ki\u201067 (<jats:styled-content style=\"fixed-case\">MIB<\/jats:styled-content>\u20101). The association between <jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content> and Ki\u201067 was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Loss of heterozygosity occurred in 5\/9 <jats:styled-content style=\"fixed-case\">AAOLL<\/jats:styled-content>s and in 2\/10 <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>s in at least one marker each, while <jats:styled-content style=\"fixed-case\">NOM<\/jats:styled-content> showed no <jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content>. Cell proliferation index in <jats:styled-content style=\"fixed-case\">AAOLL<\/jats:styled-content> ranged from 2 to 23%. There was no association between cell proliferation and <jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content>, independent of the marker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows that the profile of molecular changes in <jats:styled-content style=\"fixed-case\">AAOLL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>, evaluated by <jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content> and Ki\u201067 expression, is similar. Additional studies including larger samples should be performed to confirm or to refute our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12627","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T01:06:42Z","timestamp":1482887202000},"page":"471-476","source":"Crossref","is-referenced-by-count":4,"title":["Allelic loss in amalgam\u2010associated oral lichenoid lesions compared to oral lichen planus and mucosa"],"prefix":"10.1111","volume":"23","author":[{"given":"LN","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SF","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte 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