{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:28Z","timestamp":1740124348653,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Objective<\/jats:title>Halitosis is caused by volatile sulphur compounds including methyl mercaptan (CH<\/jats:styled-content>3<\/jats:sub>SH<\/jats:styled-content>) in the oral cavity and is a serious problem that limits interpersonal social communication. The aim of study was to evaluate the effects of reuterin\u2010related compounds (RRC<\/jats:styled-content>s) on halitosis\u2010related periodontopathic bacteria in\u00a0vitro<\/jats:italic>.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>RRC<\/jats:styled-content>\u201001, RRC<\/jats:styled-content>\u201002 and RRC<\/jats:styled-content>\u201003 (32 and 64\u00a0\u03bc<\/jats:italic>g\u00a0ml\u22121<\/jats:sup>) in culture media containing Fusobacterium nucleatum <\/jats:italic>JCM<\/jats:styled-content>8523 and Porphyromonas gingivalis <\/jats:italic>ATCC<\/jats:styled-content>33277 were used. The effects of RRC<\/jats:styled-content>s on CH<\/jats:styled-content>3<\/jats:sub>SH<\/jats:styled-content> production and detectable odour by F.\u00a0nucleatum<\/jats:italic> and P.\u00a0gingivalis<\/jats:italic> were examined by CH<\/jats:styled-content>3<\/jats:sub>SH<\/jats:styled-content> production assay and organoleptic test, respectively. The number of bacterial cells was also measured using an ATP<\/jats:styled-content> assay. In P.\u00a0gingivalis<\/jats:italic> treated with RRC<\/jats:styled-content>s, the expression of mgl<\/jats:italic> gene, which is responsible for CH<\/jats:styled-content>3<\/jats:sub>SH<\/jats:styled-content> production, was examined by q<\/jats:italic>RT<\/jats:styled-content>\u2010PCR.<\/jats:p><\/jats:sec>Results<\/jats:title>CH<\/jats:styled-content>3<\/jats:sub>SH<\/jats:styled-content> production and the score of detectable odour from F.\u00a0nucleatum<\/jats:italic> and P.\u00a0gingivalis<\/jats:italic> culture media containing RRC<\/jats:styled-content>s were significantly lower than that without RRC<\/jats:styled-content>s (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). The expression of mgl<\/jats:italic> gene in P.\u00a0gingivalis<\/jats:italic> was significantly downregulated by RRC<\/jats:styled-content>\u201001 (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01), but not by RRC<\/jats:styled-content>\u201002 or RRC<\/jats:styled-content>\u201003.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>RRC<\/jats:styled-content>s are potent oral care products for preventing halitosis via<\/jats:italic> reducing CH<\/jats:styled-content>3<\/jats:sub>SH<\/jats:styled-content> production.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12638","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T15:12:49Z","timestamp":1484320369000},"page":"492-497","source":"Crossref","is-referenced-by-count":7,"title":["Novel reuterin\u2010related compounds suppress odour by periodontopathic bacteria"],"prefix":"10.1111","volume":"23","author":[{"given":"N","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Oral 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