{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:07:10Z","timestamp":1771294030536,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acetylation and deacetylation are the most studied covalent histone modifications resulting in transcriptional regulation with histone deacetylases (<jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>) and histone acetyltransferases (<jats:styled-content style=\"fixed-case\">HAT<\/jats:styled-content>) as the main associated enzymes. These enzymes overexpression induces abnormal transcription of key genes that regulate important cellular functions, such as proliferation, cell cycle regulation, and apoptosis. Thus, the expression of different <jats:styled-content style=\"fixed-case\">HAT<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>s has been evaluated in various cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>2 and <jats:styled-content style=\"fixed-case\">HAT<\/jats:styled-content>1 expression in lip squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content>) and actinic cheilitis (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>) and to demonstrate their correlation with <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> metyltransferases (<jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Thirty cases of lip squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content>), thirty cases of actinic cheilitis (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>), and 28 cases of non\u2010neoplastic epithelium as control were selected for immunohistochemical investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nuclear <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>2 immunopositivity was significantly higher in <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> (75.07%\u00a0\u00b1\u00a029.70) when compared with <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content> (51.06%\u00a0\u00b1\u00a039.02). <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">HAT<\/jats:styled-content>1 nuclear immunostaining were higher in <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>, with no statistical significance. When comparing data with our previous study, we found a positive correlation between <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>1 X <jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>3b, <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>2 X <jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>3b, and <jats:styled-content style=\"fixed-case\">HAT<\/jats:styled-content>1 X <jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>3b for certain studied groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed higher levels of nuclear <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>2 immunopositivity in <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>, possibly indicating that this enzyme plays a key role in lip photocarcinogenesis early stages.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12641","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T22:05:16Z","timestamp":1484949916000},"page":"505-510","source":"Crossref","is-referenced-by-count":20,"title":["Immunoexpression of <scp>HDAC<\/scp>1, <scp>HDAC<\/scp>2, and <scp>HAT<\/scp>1 in actinic cheilitis and lip squamous cell carcinoma"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5569-9371","authenticated-orcid":false,"given":"ES","family":"Chrun","sequence":"first","affiliation":[{"name":"Federal University of Santa Catarina Florianopolis Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Modolo","sequence":"additional","affiliation":[{"name":"Pathology Department and Dentistry Graduate Program Federal University of Santa Catarina Florianopolis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DSC","family":"Vieira","sequence":"additional","affiliation":[{"name":"Pathology Department Federal University of Santa Catarina Florianopolis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1LS","family":"Borges\u2010J\u00fanior","sequence":"additional","affiliation":[{"name":"Federal University of Santa Catarina Florianopolis Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RG","family":"Castro","sequence":"additional","affiliation":[{"name":"Dentistry Department Federal University of Santa Catarina Florianopolis Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FI","family":"Daniel","sequence":"additional","affiliation":[{"name":"Pathology Department and Dentistry Graduate Program Federal University of Santa Catarina Florianopolis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/1117-6806.179832"},{"key":"e_1_2_7_3_1","volume-title":"World Heath Organization classification of tumors pathology and genetics of the head and neck tumors","author":"Barnes L","year":"2005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12140"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/35094059"},{"key":"e_1_2_7_6_1","first-page":"109","article-title":"Surgical attitude in premalignant lesions and malignant tumors of the lower lip","volume":"8","author":"Calcaianu N","year":"2015","journal-title":"J Med Life"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.08.011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2001.tb02153.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(200007)184:1<1::AID-JCP1>3.0.CO;2-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12453"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140612222"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1279"},{"key":"e_1_2_7_13_1","volume-title":"Cancer Incidence and Mortality Worldwide: IARC CancerBase. 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