{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:28Z","timestamp":1740124348081,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to determine whether rebamipide, an antistomach ulcer agent, ameliorated benzodiazepine\u2010induced hyposalivation in rat parotid gland (<jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>) and submandibular gland (<jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Saliva was collected from <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content> through a capillary cannula inserted into the parotid duct and sublingual papillae, respectively, every 15\u00a0min for 1\u00a0h after stimulation with pilocarpine dissolved in physiological saline and intraperitoneally administered at 1\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>. Diazepam (<jats:styled-content style=\"fixed-case\">DZP<\/jats:styled-content>) was administered intraperitoneally at a dose of 0.2\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> twice daily for 7\u00a0days. Rebamipide was administered at 10, 20, 30, or 100\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> concomitantly with <jats:styled-content style=\"fixed-case\">DZP<\/jats:styled-content> to determine its effect on hyposalivation. The effect of rebamipide on movement of intracellular calcium ([Ca<jats:sup>2+<\/jats:sup>]<jats:italic>i<\/jats:italic>) in isolated parotid acinar cells was analyzed using Fluo4, a fluorescent dye used to detect Ca<jats:sup>2+<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Repetitive administration of <jats:styled-content style=\"fixed-case\">DZP<\/jats:styled-content> decreased salivary secretion in <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SMG<\/jats:styled-content>. This inhibitory effect was weakened by administration of rebamipide. Prior administration of <jats:styled-content style=\"fixed-case\">DZP<\/jats:styled-content> (10<jats:sup>\u22126<\/jats:sup>M) significantly suppressed carbachol (10<jats:sup>\u22127<\/jats:sup>M)\u2010induced increase in [Ca<jats:sup>2+<\/jats:sup>]<jats:italic>i<\/jats:italic>. This inhibitory effect was ameliorated by combined use with rebamipide (5\u00a0\u00d7\u00a010<jats:sup>\u22124<\/jats:sup>M).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This findings suggest that rebamipide weakens the downregulatory effect of <jats:styled-content style=\"fixed-case\">DZP<\/jats:styled-content> on salivary secretion by preventing <jats:styled-content style=\"fixed-case\">DZP<\/jats:styled-content>\u2010induced suppression of increase in [Ca<jats:sup>2+<\/jats:sup>]<jats:italic>i<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12642","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T12:52:43Z","timestamp":1485262363000},"page":"511-517","source":"Crossref","is-referenced-by-count":0,"title":["Rebamipide, an anti\u2010ulcerative drug, inhibits induction of salivary dysfunction by 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Tsukagoshi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Tokyo Dental College Chiyoda\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Tokyo Dental College Chiyoda\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198308183090705"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00232909"},{"key":"e_1_2_7_4_1","first-page":"291","article-title":"Coupling of benzodiazepine and GABA(A) receptors in the salivary glands is a factor of drug\u2010induced xerostomia","volume":"11","author":"Kawaguchi M","year":"1996","journal-title":"Int Acad Biomed Drug 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