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Nicotine is shown to have antiproliferative properties and affects fibroblasts <jats:italic>in\u00a0vitro,<\/jats:italic> which may interfere in tissue myofibroblast differentiation in e\u2010cig users. This will affect the ability to heal wounds by decreasing wound contraction. In periodontics, direct exposure to e\u2010vapor has been shown to produce harmful effects in periodontal ligament and gingival fibroblasts in culture. This is due to the generation of reactive oxygen species\/aldehydes\/carbonyls from e\u2010cig aerosol, leading to protein carbonylation of extracellular matrix and <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> adducts\/damage. A limited number of studies regarding the effects of e\u2010cig in oral and lung health are available. However, no reports are available to directly link the deleterious effects on e\u2010cigs, inhaled nicotine, and flavorings aerosol on periodontal and pulmonary health in particular to identify the risk of oral diseases by e\u2010cigarettes and nicotine aerosols. This mini\u2010review summarizes the recent perspectives on e\u2010cigarettes including inhaled nicotine effects on several pathophysiological events, such as oxidative stress, <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage, innate host response, inflammation, cellular senescence, profibrogenic and dysregulated repair, leading to lung remodeling, oral submucous fibrosis, and periodontal diseases.<\/jats:p>","DOI":"10.1111\/odi.12652","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T03:56:50Z","timestamp":1486439810000},"page":"1052-1057","source":"Crossref","is-referenced-by-count":105,"title":["Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues"],"prefix":"10.1111","volume":"23","author":[{"given":"F","family":"Javed","sequence":"first","affiliation":[{"name":"Department of General Dentistry Eastman Institute for Oral Health University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SV","family":"Kellesarian","sequence":"additional","affiliation":[{"name":"Department of General Dentistry Eastman Institute for Oral Health University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IK","family":"Sundar","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine University of Rochester Medical Center Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GE","family":"Romanos","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dental Medicine Stony Brook University Stony Brook NY USA"},{"name":"Department of Oral Surgery and Implant Dentistry Johann Wolfgang Goethe University Dental School Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-2454","authenticated-orcid":false,"given":"I","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine University of Rochester Medical Center Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160427"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.1.13"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.01041.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.02.002"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.14830"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00079-X"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-09-00050"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/002203459607502S07"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1057\/jphp.2010.41"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-5-27"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2014.04.012"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00844.x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00396.2012"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/tobaccocontrol-2013-051482"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1105249"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100200"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/08958378.2012.758197"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.070060"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0109OC"},{"key":"e_1_2_13_21_1","first-page":"26","article-title":"[Effects of arecoline and nicotine on the expression of hTERT in oral keratinocytes]. 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