{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T13:54:49Z","timestamp":1781963689683,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005634","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riseura Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004092","name":"Kuopion Yliopistollinen Sairaala","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Objective<\/jats:title>To carry out a double\u2010blind randomized controlled trial (RCT<\/jats:styled-content>) to compare the effectiveness of topical tacrolimus (TAC<\/jats:styled-content>), triamcinolone acetonide (TRI<\/jats:styled-content>), and placebo (PLA<\/jats:styled-content>) in symptomatic oral lichen planus (OLP<\/jats:styled-content>).<\/jats:p><\/jats:sec>Subjects and Methods<\/jats:title>A clinical score (CS<\/jats:styled-content>, range 0\u2013130) was developed to measure the clinical signs and symptoms of OLP<\/jats:styled-content>. Twenty\u2010seven OLP<\/jats:styled-content> patients with a CS<\/jats:styled-content> of \u226520 were randomly allocated to receive 0.1% TAC<\/jats:styled-content> ointment (n<\/jats:italic>\u00a0=\u00a011), 0.1% TRI<\/jats:styled-content> paste (n<\/jats:italic>\u00a0=\u00a07), or Orabase\u00ae<\/jats:sup> paste as PLA<\/jats:styled-content> (n<\/jats:italic>\u00a0=\u00a09) for 3\u00a0weeks. If the CS<\/jats:styled-content> dropped \u226520% (interpreted as response), the patients continued the same medication for another 3\u00a0weeks. If the CS<\/jats:styled-content> dropped <20% or increased (non\u2010response), the patients were switched to TAC<\/jats:styled-content> for 6\u00a0weeks. A 6\u2010month follow\u2010up period ensued. The primary outcome variable was the change in CS<\/jats:styled-content> from baseline to week 3. In primary outcome analysis, CS<\/jats:styled-content> values between the treatment arms were compared.<\/jats:p><\/jats:sec>Results<\/jats:title>Tacrolimus and TRI<\/jats:styled-content> were more effective (P<\/jats:italic>\u00a0=\u00a00.012 and 0.031, respectively) than PLA<\/jats:styled-content> in reducing the CS<\/jats:styled-content> at week 3. No difference in the efficacy was noted between TAC<\/jats:styled-content> and TRI<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00.997).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This pilot RCT<\/jats:styled-content> provides evidence for the effectiveness of TAC<\/jats:styled-content> and TRI<\/jats:styled-content> over PLA<\/jats:styled-content> in the management of OLP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12653","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T04:02:47Z","timestamp":1486440167000},"page":"660-668","source":"Crossref","is-referenced-by-count":31,"title":["Topical tacrolimus, triamcinolone acetonide, and placebo in oral lichen planus: a pilot randomized controlled trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2357-830X","authenticated-orcid":false,"given":"M","family":"Siponen","sequence":"first","affiliation":[{"name":"Institute of Dentistry University of Oulu Oulu Finland"},{"name":"Cancer and Translational Medicine Research Unit University of Oulu Oulu Finland"},{"name":"Department of Oral and Maxillofacial Diseases Kuopio University Hospital Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Huuskonen","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kallio\u2010Pulkkinen","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Nieminen","sequence":"additional","affiliation":[{"name":"Medical Informatics and Statistics Research Group University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Salo","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Oulu Oulu Finland"},{"name":"Cancer and Translational Medicine Research Unit University of Oulu Oulu Finland"},{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki Helsinki Finland"},{"name":"Medical Research Center Oulu University Hospital Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,31]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"99","article-title":"The comparison of efficacy of adcortyl ointment and topical tacrolimus in treatment of erosive oral lichen planus","volume":"1","author":"Azizi A","year":"2007","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1999.tb00063.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.06.022"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000118"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2010.07.014"},{"key":"e_1_2_8_8_1","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01191.x"},{"issue":"7","key":"e_1_2_8_10_1","first-page":"CD009864","article-title":"Topical tacrolimus for atopic dermatitis","author":"Cury Martins J","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120452"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08106.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_8_14_1","first-page":"133","article-title":"Pain measurement tools for clinical practice and research","volume":"64","author":"Flaherty SA","year":"1996","journal-title":"AANA J"},{"key":"e_1_2_8_15_1","unstructured":"Food and Drug Administration(2006).Information for healthcare professionals: tacrolimus (marketed as Protopic). 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