{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:29:45Z","timestamp":1787243385081,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Saudi Arabian Ministry of Higher Education and the Cultural Bureau, Berlin, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aim of the study was to determine the levels of salivary epidermal growth factor (\n                      <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>\n                      ) and vascular endothelial growth factor (\n                      <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                      ) as well as interleukin\u20108 (\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20108) in patients with geographic tongue (\n                      <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>\n                      ), as compared to control subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      An enzyme\u2010linked immunosorbent assay was used to measure the levels of\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20108,\n                      <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                      in whole saliva samples collected from 34 patients with\n                      <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>\n                      and 38 control subjects. The patients and controls were grouped and matched according to age, gender and the presence of systemic diseases, which are factors that may influence the levels of salivary biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All patients with\n                      <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>\n                      displayed significantly higher levels of\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20108 than the controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The young female patients also showed reduced levels of\n                      <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) and\n                      <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), as compared to the young male patients where no such differences were observed. Interestingly, high levels of\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20108 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and\n                      <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) were detected in the patients with\n                      <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>\n                      who also suffered from hypertension.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We consider\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20108 an inflammatory mediator, which contributes to the acute inflammatory response found in\n                      <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                      also seem to be involved in the pathophysiology of\n                      <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.12654","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T13:02:48Z","timestamp":1486558968000},"page":"757-762","source":"Crossref","is-referenced-by-count":15,"title":["Salivary levels of interleukin\u20108 and growth factors are modulated in patients with geographic tongue"],"prefix":"10.1111","volume":"23","author":[{"given":"A","family":"Dafar","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Pathology Institute of Odontology The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bankvall","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology Institute of Odontology The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Garsj\u00f6","sequence":"additional","affiliation":[{"name":"Clinic for Hospital Dentistry, Bor\u00e5s Hospital, Public Dental Health, Region V\u00e4stra G\u00f6taland Bor\u00e5s Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Jontell","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology Institute of Odontology The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4363-8667","authenticated-orcid":false,"given":"H","family":"\u00c7evik\u2010Aras","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology Institute of Odontology The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000148250"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116650"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01379-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.2.e163"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-95-3-776"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2014.04.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2015.1087046"},{"key":"e_1_2_8_9_1","first-page":"313","article-title":"The relationship between geographic tongue and stress","volume":"12","author":"Ebrahimi H","year":"2010","journal-title":"Iran Red Crescent Med J"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.2000.0585"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0198"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrc.2016.01.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411950060020101"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0320"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2014.03.010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.8.929"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2340\/0001555564191196","article-title":"Ultrastructure of oral mucous membrane lesions in psoriasis","volume":"64","author":"Kanerva L","year":"1984","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1986.tb01516.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1986.tb00584.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.08.012"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt712"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007999809113354"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126190"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1981.tb00789.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/25.1.9"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-010-9251-7"},{"key":"e_1_2_8_27_1","first-page":"E620","article-title":"Effect of salivary epidermal growth factor on wound healing of tongue in mice","volume":"260","author":"Noguchi S","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(1998100)186:2<186::AID-PATH148>3.0.CO;2-J"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51102"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/908468"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.19286"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2007.06.009"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2015.1121983"},{"key":"e_1_2_8_34_1","first-page":"869","article-title":"Vascular endothelial growth factor in normal human salivary glands and saliva: a possible role in the maintenance of mucosal homeostasis","volume":"78","author":"Taichman NS","year":"1998","journal-title":"Lab Invest"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.02.005"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/000163599428995"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:16:10Z","timestamp":1695478570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,24]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/odi.12654"],"URL":"https:\/\/doi.org\/10.1111\/odi.12654","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,24]]}}}