{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:41:25Z","timestamp":1790023285296,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81000438"],"award-info":[{"award-number":["81000438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14411971800"],"award-info":[{"award-number":["14411971800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The bacterial community structure of buccal mucosa in patients with oral lichen planus was evaluated and compared with healthy control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Buccal scraping samples have been taken on 43 oral lichen planus patients (21 erosive and 22 non\u2010erosive) and 21 mucosal healthy volunteers. The V3 hypervariable 16S <jats:styled-content style=\"fixed-case\">rDNA<\/jats:styled-content> region was amplified and sequenced by high\u2010throughput 454 pyrosequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>94.26% of the total buccal bacteria were classified into 15 abundant genera. Eight of these abundant genera could be detected in all cases, namely <jats:italic>Streptococcus<\/jats:italic>,<jats:italic> Prevotella<\/jats:italic>,<jats:italic> Haemophilu<\/jats:italic>,<jats:italic> Neisseria<\/jats:italic>,<jats:italic> Fusobacterium<\/jats:italic>,<jats:italic> Leptotrichia<\/jats:italic>,<jats:italic> Veillonella<\/jats:italic> and <jats:italic>Actinomyces<\/jats:italic>. Four abundant bacteria showed significantly different prevalence at the genus level: <jats:italic>Streptococcus<\/jats:italic> was more abundant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) in healthy control group, while <jats:italic>Fusobacterium<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), <jats:italic>Leptotrichia<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and <jats:italic>Lautropia<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) showed higher abundance in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> group. Few differences can be found between erosive and non\u2010erosive <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. In general, 19 \u2018core\u2019 <jats:styled-content style=\"fixed-case\">OTU<\/jats:styled-content>s at three levels were defined to be <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> specific, comparing with healthy control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> is associated with dysbiosis of the oral microbiome. Further studies should be taken to elucidate the inner relationship between these observed changes and <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12657","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T18:02:15Z","timestamp":1487181735000},"page":"674-682","source":"Crossref","is-referenced-by-count":77,"title":["Dysbiosis of oral buccal mucosa microbiota in patients with oral lichen planus"],"prefix":"10.1111","volume":"23","author":[{"given":"Y","family":"He","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, School &amp; Hospital of Stomatology, Tongji University Shanghai Engineering Research Center of Tooth Restoration and Regeneration Shanghai 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