{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:29:10Z","timestamp":1767983350747,"version":"3.49.0"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Selcuk University Scientific Research Center","award":["11102024"],"award-info":[{"award-number":["11102024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to investigate the gingival crevicular fluid (<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>) levels of monocyte chemoattractant protein (<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>)\u20101 in aggressive periodontitis (AgP) and whether <jats:styled-content style=\"fixed-case\">GCF MCP<\/jats:styled-content>\u20101 levels differ among localized (L) AgP and generalized (G) AgP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 160 subjects including 80 AgP and 80 age\u2010 and gender\u2010matched periodontally healthy (H) controls were recruited in this cross\u2010sectional study <jats:italic>(<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>02927704)<\/jats:italic>. <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> samples were collected from 160 patients including 50 <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP, 30 <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>gP, and 80 H. Volume of <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> was measured by Periotron 8000<jats:sup>\u00ae<\/jats:sup>, and enzyme\u2010linked immunosorbent assay was used to assess <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to H controls, all clinical parameters and total amounts (pg\u00a030\u00a0s<jats:sup>\u22121<\/jats:sup>) of <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 were significantly higher in subjects with <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP and <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>gP (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Although concentrations of <jats:styled-content style=\"fixed-case\">GCF MCP<\/jats:styled-content>\u20101 did not differ between <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP and <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>gP (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05), total amounts of <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 were higher in <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>gP than <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It can be concluded that the total amount of <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 level in <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> may be a potential determinant in AgP subjects. Increased <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 levels in line with the degree of periodontal destruction in <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>gP patients reveal that <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 can be used to understand the disease pathogenesis of <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>gP and <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>gP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12658","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T22:44:56Z","timestamp":1487889896000},"page":"763-769","source":"Crossref","is-referenced-by-count":19,"title":["Gingival crevicular fluid levels of monocyte chemoattractant protein\u20101 in patients with aggressive 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