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Importantly, the status of serum 25\u2010hydroxyvitamin D of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> patients was reduced consistently. In a cultured cell model, 1,25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> could downregulate excessive production of pro\u2010inflammatory factors induced by lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>) in keratinocyte HaCat cells. Mechanistically, even though <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced cytokines in keratinocytes were inhibited both by nuclear factor\u2010<jats:italic>\u03ba<\/jats:italic>B (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:italic>\u03ba<\/jats:italic>B) inhibitor and by activator protein 1 (<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\u20101) inhibitor, <jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>\u2010dependent 1,25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> blocked the activation of phosphorylated\u2010<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:italic>\u03ba<\/jats:italic>B p65 rather than c\u2010Jun\/c\u2010Fos in the presence of <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that 1,25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> plays an anti\u2010inflammatory role in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> by mediating <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:italic>\u03ba<\/jats:italic>B signaling pathway but not <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\u20101 signaling pathway with a <jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>\u2010dependent manner, predicting vitamin D supplement may be a potential strategy for the <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12659","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T22:43:20Z","timestamp":1487889800000},"page":"770-778","source":"Crossref","is-referenced-by-count":39,"title":["Experimental study on 1,25(<scp>OH<\/scp>)<sub>2<\/sub>D<sub>3<\/sub> amelioration of oral lichen planus through regulating NF\u2010<i>\u03ba<\/i>B signaling pathway"],"prefix":"10.1111","volume":"23","author":[{"given":"J","family":"Du","sequence":"first","affiliation":[{"name":"Department of Stomatology Shanxi Medical University Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shanxi Medical University Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shanxi Medical University 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