{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:07:51Z","timestamp":1790190471391,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91649124"],"award-info":[{"award-number":["91649124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The goals of this study were to (i) establish a useful miniature pig (minipig) model for irradiation\u2010induced oral mucositis and (ii) evaluate the effect of Tempol to prevent its development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>Minipigs were irradiated with 6\u00a0Gy for five consecutive days targeting the entire oral cavity. To prevent radiation damage, minipigs were treated with 30\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> Tempol 10\u00a0min before irradiation (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), while the radiation\u2010alone group was similarly injected with saline (<jats:italic>n<\/jats:italic>\u00a0=\u00a04). Lesions were graded using an oral mucositis score and visual inspection every 3\u00a0days, and biopsy of multiple sites was performed at day 18. Weight and chest and abdominal circumferences were measured every 3\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lesions began about 12\u00a0days after the first irradiation fraction and healed about 30\u00a0days after irradiation. Epithelial thickness was calculated on the lingual and buccal mucosa on the 18th day after the first irradiation fraction. Tempol provided modest protection from ulceration after irradiation using this treatment strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study established a useful large animal model for irradiation\u2010induced oral mucositis and showed modest beneficial effects of Tempol in limiting tissue damage. The latter finding may be potentially valuable in preventing oral mucositis in patients receiving irradiation for head and neck cancers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12667","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T02:13:51Z","timestamp":1490235231000},"page":"801-808","source":"Crossref","is-referenced-by-count":16,"title":["Effect of Tempol on the prevention of irradiation\u2010induced mucositis in miniature pigs"],"prefix":"10.1111","volume":"23","author":[{"given":"L","family":"Hu","sequence":"first","affiliation":[{"name":"Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Capital Medical University School of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Wang","sequence":"additional","affiliation":[{"name":"Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Capital Medical University School of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AP","family":"Cotrim","sequence":"additional","affiliation":[{"name":"Molecular Physiology and Therapeutics Branch National Institute of Dental and Craniofacial Research NIH DHHS Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Zhu","sequence":"additional","affiliation":[{"name":"Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Capital Medical University School of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Gao","sequence":"additional","affiliation":[{"name":"Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Capital Medical University School of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Zheng","sequence":"additional","affiliation":[{"name":"Molecular Physiology and Therapeutics Branch National Institute of Dental and Craniofacial Research NIH DHHS Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CM","family":"Goldsmith","sequence":"additional","affiliation":[{"name":"Molecular Physiology and Therapeutics Branch National Institute of Dental and Craniofacial Research NIH DHHS Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Jin","sequence":"additional","affiliation":[{"name":"Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Capital Medical University School of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Zhang","sequence":"additional","affiliation":[{"name":"Salivary Gland Disease Center and 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Beijing China"},{"name":"Department of Biochemistry and Molecular Biology Capital Medical University School of Basic Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40496-015-0069-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24134"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2014.12.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-S104"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0958"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0662"},{"key":"e_1_2_7_8_1","first-page":"273","article-title":"Protection from radiation\u2010induced alopecia with topical application of nitroxides: fractionated 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