{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:23:22Z","timestamp":1789759402602,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:00:00Z","timestamp":1494979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008919","name":"Faculty of Dentistry, McGill University","doi-asserted-by":"publisher","award":["2011"],"award-info":[{"award-number":["2011"]}],"id":[{"id":"10.13039\/100008919","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The association between body mass index (\n                      <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                      ) and oral diseases was investigated, and levels of obesity\u2010related inflammatory mediators were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>\n                      Participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0160) were clinically and radiographically examined for oral diseases. Blood profiles were recorded. Levels of adiponectin, leptin, and C\u2010reactive protein (\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      ) were measured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and thirteen (70.6%) participants had overweight or obese status (\n                      <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                      \u00a0\u2265\u00a023.0\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). Sum of dental diseases and severe periodontitis were higher in overweight or obese individuals than in normal\u2010weight participants (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .037 and\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .002, respectively). A significant difference in oral mucosal disorders between normal weight and overweight or obesity was not found. Plasma leukocyte counts, liver enzymes, leptin, and\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      levels were increased while adiponectin levels were decreased in individuals with\n                      <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                      \u226523.0\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      compared with normal\u2010weight participants. After adjusting for age, sex, fasting plasma glucose level, smoking, and exercise, obesity was associated with sum of dental diseases (\u00df\u00a0=\u00a00.239,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.013), severe periodontitis (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      =4.52; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.37, 14.95,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .013), adiponectin (\u00df\u00a0=\u00a0\u20130.359,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .001), leptin (\u00df\u00a0=\u00a00.630,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .001), and\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      levels (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      =12.66; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      3.07, 52.21,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overweight or obese Thai people were related to an increase in inflammatory dental and periodontal diseases with an altered health profile and plasma inflammatory mediators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.12679","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T01:02:53Z","timestamp":1494982973000},"page":"956-965","source":"Crossref","is-referenced-by-count":31,"title":["Increased oral inflammation, leukocytes, and leptin, and lower adiponectin in overweight or obesity"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-0658","authenticated-orcid":false,"given":"S","family":"Thanakun","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Periodontology Faculty of Dentistry Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Pornprasertsuk\u2010Damrongsri","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology Faculty of Dentistry Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-433X.176476"},{"key":"e_1_2_8_3_1","first-page":"95","article-title":"Oral fluid based biomarkers in periodontal disease: Part 1. 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