{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:53Z","timestamp":1787015933264,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000027","name":"Institute of Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,10]]},"abstract":"\n Objectives<\/jats:title>\n \n To describe parotid gland (\n PG<\/jats:styled-content>\n ) saliva organic and inorganic composition and flow rate changes, after curative intensity\u2010modulated radiotherapy (\n IMRT<\/jats:styled-content>\n ) for head and neck cancer (\n HNC<\/jats:styled-content>\n ), and analyse the relationship between\n PG<\/jats:styled-content>\n saliva analytes and xerostomia measures.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Materials<\/jats:title>\n \n Twenty\u2010six patients recruited to five prospective phase 2 or 3 trials which assessed toxicity and efficacy of\n IMRT<\/jats:styled-content>\n by\n HNC<\/jats:styled-content>\n subsite, provided longitudinal\n PG<\/jats:styled-content>\n saliva. Salivary flow rate, and subjective and objective xerostomia measures were prospectively collected and saliva tested for inorganic and organic analytes. Statistical comparisons of longitudinal analyte changes and analysis for a relationship between dichotomized xerostomia score and saliva analytes were performed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred and forty\u2010two\n PG<\/jats:styled-content>\n saliva samples from 26 patients were analysed. At 3\u20136\u00a0months after\n IMRT<\/jats:styled-content>\n , stimulated and unstimulated saliva showed significantly decreased flow rate, total protein (\n TP<\/jats:styled-content>\n ) secretion rate, phosphate concentration and increased lactoferrin (\n LF<\/jats:styled-content>\n ) concentration. Stimulated saliva alone had elevated\n LF<\/jats:styled-content>\n secretion rate and beta\u20102\u2010microglobulin (B\n 2<\/jats:sub>\n M) concentration with decreased calcium (Ca\n 2+<\/jats:sup>\n ) and magnesium (Mg\n 2+<\/jats:sup>\n ) concentrations and Ca\n 2+<\/jats:sup>\n secretion rate. At >12\u00a0months, under stimulated and unstimulated conditions, increased\n LF<\/jats:styled-content>\n concentration and decreased Mg\n 2+<\/jats:sup>\n and phosphate concentration persisted and, in stimulated saliva, there was decreased potassium (K\n +<\/jats:sup>\n ) and Mg\n 2+<\/jats:sup>\n concentration. Unstimulated\n TP<\/jats:styled-content>\n secretion rate was lower in the presence of high\u2010grade xerostomia. Otherwise, no relationship between xerostomia grade and\n PG<\/jats:styled-content>\n salivary flow rate,\n TP<\/jats:styled-content>\n and Ca\n 2+<\/jats:sup>\n secretion rate was found.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Fewer significant differences in\n PG<\/jats:styled-content>\n saliva analytes >12\u00a0months after\n IMRT<\/jats:styled-content>\n indicate good functional recovery. Residual xerostomia after\n IMRT<\/jats:styled-content>\n will only be further reduced by addressing the sparing of subsites of the\n PG<\/jats:styled-content>\n or other salivary gland tissues, in addition to the\n PG<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/odi.12686","type":"journal-article","created":{"date-parts":[[2017,4,23]],"date-time":"2017-04-23T07:22:52Z","timestamp":1492932172000},"page":"990-1000","source":"Crossref","is-referenced-by-count":25,"title":["The effect of parotid gland\u2010sparing intensity\u2010modulated radiotherapy on salivary composition, flow rate and xerostomia measures"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2054-9311","authenticated-orcid":false,"given":"TM","family":"Richards","sequence":"first","affiliation":[{"name":"Head and Neck Unit Royal Marsden Hospitals NHS Foundation Trust London Surrey 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