{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:15:53Z","timestamp":1789679753103,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Objectives<\/jats:title>Keratocystic odontogenic tumor (KCOT<\/jats:styled-content>) demonstrates variable growth mechanisms and biologic behavior, partly due to origin and histology. We looked for the most contributing factors in predicting outcome of treatment.<\/jats:p><\/jats:sec>Subjects and Methods<\/jats:title>We retrospectively reviewed 118 medical files of patients diagnosed with KCOT<\/jats:styled-content> (by tissue biopsy before surgical treatment) with\/without nevoid basal cell carcinoma syndrome (NBCCS<\/jats:styled-content>) from 1995 to 2015. Data were recorded and analyzed statistically to determine the treatment\u2013outcome correlation. KCOT<\/jats:styled-content>s in NBCCS<\/jats:styled-content> patients were termed \u201csyndromic\u201d and random KCOT<\/jats:styled-content>s termed \u201csporadic.\u201d<\/jats:p><\/jats:sec>Results<\/jats:title>Of 102 cysts, 32 were diagnosed with NBCCS<\/jats:styled-content>. Sporadic KCOT<\/jats:styled-content>s were significantly larger upon diagnosis (p<\/jats:italic>\u00a0<\u00a0.017). Factors most indicative of postsurgical complications are older age (p\u00a0<\/jats:italic><\u00a0.011), upper jaw location, and size of lesion \u22659.5\u00a0cm\u00b2. Sporadic KCOT<\/jats:styled-content>s significantly increased the chances of complications approximately threefold (p<\/jats:italic>\u00a0<\u00a0.043). Higher recurrence rate was significant in syndromic cysts (47%) compared to sporadic cysts (20%) (p\u00a0<\/jats:italic><\u00a0.009). Recurrence time was 3\u00a0years on average.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Postsurgical complications may be expected in: older patients, upper jaw location, extensive lesions, and sporadic KCOT<\/jats:styled-content>. Most KCOT<\/jats:styled-content> recurrence is diagnosed 3\u00a0years from treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12687","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T22:08:43Z","timestamp":1493330923000},"page":"1058-1065","source":"Crossref","is-referenced-by-count":19,"title":["Sporadic versus syndromic keratocysts\u2014Can we predict treatment outcome? A review of 102 cysts"],"prefix":"10.1111","volume":"23","author":[{"given":"D","family":"Noy","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery the Clinical Research Institute and the Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Rachmiel","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery the Clinical Research Institute and the Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Zar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery the Clinical Research Institute and the Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Emodi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery the Clinical Research Institute and the Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3112-2273","authenticated-orcid":false,"given":"RM","family":"Nagler","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery the Clinical Research Institute and the Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.01.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.03.020"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(76)90031-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4802449"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4802732"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2004.04.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2011.07.003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198703000-00002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196005052621803"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.113109"},{"key":"e_1_2_7_12_1","unstructured":"Neville B. 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