{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:39:55Z","timestamp":1780346395388,"version":"3.54.1"},"reference-count":61,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondo Trieste 2008"},{"name":"Regione FVG","award":["L.26.2008"],"award-info":[{"award-number":["L.26.2008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Objectives<\/jats:title>Chronic periodontitis is a common pathological condition that affects the supporting tissue of the teeth, leading to progressive alveolar bone destruction and teeth loss. The disease is caused by bacteria and derives from an altered host immune and inflammatory response, also involving different factors such as the oral hygiene, smoking, and genetic background. The innate immune response, the first line of host defense, could also play an important role in the susceptibility to chronic periodontitis. In this study, we evaluated the possible association between periodontal disease and seven genetic variations within DEFB<\/jats:styled-content>1<\/jats:italic> and LTF<\/jats:styled-content><\/jats:italic> genes, encoding for \u03b2\u2010defensins 1 and lactoferrin (two members of oral innate immune system), in an Italian isolated population.<\/jats:p><\/jats:sec>Subjects and Methods<\/jats:title>DEFB<\/jats:styled-content>1<\/jats:italic> 5\u2032UTR<\/jats:styled-content> g. \u201052G>A (rs1799946), g. \u201044C>G (rs1800972), g. \u201020G>A (rs11362), 3\u2032UTR<\/jats:styled-content> c*5G>A (rs1047031), c*87A>G (rs1800971), LTF<\/jats:styled-content><\/jats:italic> p.Ala29Thr (rs1126477), and p.Lys47Arg (rs1126478) single nucleotide polymorphisms (SNPs) were analyzed in 155 healthy individuals and 439 chronic periodontitis patients from North\u2010East Italy.<\/jats:p><\/jats:sec>Results<\/jats:title>Significant associations were found between periodontitis and g. \u201020G>A (rs11362) and g. \u201044C>G (rs1800972) SNP<\/jats:styled-content>s in DEFB<\/jats:styled-content>1<\/jats:italic> gene as well as p.Ala29Thr (rs1126477) and p.Lys47Arg (rs1126478) SNP<\/jats:styled-content>s in LTF<\/jats:styled-content><\/jats:italic> gene.<\/jats:p><\/jats:sec>Discussion<\/jats:title>Our results suggest the involvement of DEFB<\/jats:styled-content>1<\/jats:italic> and LTF<\/jats:styled-content><\/jats:italic> genetic variations in the susceptibility toward development of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12689","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T07:58:43Z","timestamp":1494316723000},"page":"1001-1008","source":"Crossref","is-referenced-by-count":28,"title":["LTF<\/scp><\/i> and DEFB<\/scp>1<\/i> polymorphisms are associated with susceptibility toward chronic periodontitis development"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5886-9129","authenticated-orcid":false,"given":"L","family":"Zupin","sequence":"first","affiliation":[{"name":"Department of Surgical, Medical and Health Sciences University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Robino","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CO","family":"Navarra","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Health Sciences University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Pirastu","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Health Sciences University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Di Lenarda","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Health Sciences University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Gasparini","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Health Sciences University of Trieste Trieste Italy"},{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Crovella","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Health Sciences University of Trieste Trieste Italy"},{"name":"Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Bevilacqua","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Health Sciences University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb01755.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.327545"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1128\/iai.32.2.655-660.1981","article-title":"Bactericidal activity of human lactoferrin: Influence of physical conditions and metabolic state of the target microorganism","volume":"32","author":"Arnold R. 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