{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:08:48Z","timestamp":1775156928841,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>In the process of carcinogenesis, lipid peroxidation and increased oxidative stress lead to changes in certain antioxidants. This study was aimed to assess and co\u2010relate serum levels of ceruloplasmin in oral premalignancies and oral cancer so as to gauge its possible association with the process of carcinogenesis and to determine its role as tumor marker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The study population comprised of 300 participants, equally divided into six study groups, that is, oral submucous fibrosis (<jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content>), oral leukoplakia (<jats:styled-content style=\"fixed-case\">OL<\/jats:styled-content>), nicotina stomatitis (<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>), oral malignancy (<jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content>), controls (C), and healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>); 5\u00a0ml of blood was collected from ante cubital vein from each participant. The serum was analyzed for ceruloplasmin levels using <jats:styled-content style=\"fixed-case\">ERBA CHEM<\/jats:styled-content> 5 <jats:styled-content style=\"fixed-case\">PLUS<\/jats:styled-content> semiautomated chemistry analyzer and diagnostic kit by turbidimetric immunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were total 242 males and 58 females, who were between 18 and 82\u00a0years of age, with a mean of 45.31\u00a0\u00b1\u00a013.97\u00a0years. The serum ceruloplasmin levels were significantly increased in <jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OSMF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OL<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> groups as compared to C and <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). No statistically significant difference was found in intragroup analysis of the disease groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum ceruloplasmin can be used as diagnostic marker for oral premalignant and malignant lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12690","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T11:02:38Z","timestamp":1495018958000},"page":"1066-1071","source":"Crossref","is-referenced-by-count":15,"title":["Determination of role of ceruloplasmin in oral potentially malignant disorders and oral malignancy\u2014A cross\u2010sectional study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-7639","authenticated-orcid":false,"given":"P H","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology Darshan Dental College and Hospital  Udaipur India"},{"name":"Department of Oral Medicine and Radiology K. M. Shah Dental College and Hospital Sumandeep Vidyapeeth University  Vadodara India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology K. M. Shah Dental College and Hospital Sumandeep Vidyapeeth University  Vadodara India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C B","family":"More","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology K. M. 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