{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:43:29Z","timestamp":1788493409435,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>In oral cancer, acquisition of \u03b1\u2010smooth muscle actin (\u03b1\u2010<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>)\u2010positive fibroblasts, known as myofibroblasts or carcinoma\u2010associated fibroblasts (<jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>), is an important event for progression and metastasis. However, the contribution of myofibroblasts in oral potentially malignant disorders (<jats:styled-content style=\"fixed-case\">OPMD<\/jats:styled-content>) remains controversial. This systematic review provides evidence that immunodetection of myofibroblasts may identify oral submucous fibrosis (<jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content>) with high risk of malignant transformation, but does not represent an auxiliary tool to predict the malignant potential of leukoplakia and erythroplakia, the most common <jats:styled-content style=\"fixed-case\">OPMD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/odi.12694","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T14:30:50Z","timestamp":1519655450000},"page":"84-88","source":"Crossref","is-referenced-by-count":21,"title":["Myofibroblasts in oral potentially malignant disorders: Is it related to malignant transformation?"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5285-3046","authenticated-orcid":false,"given":"RD","family":"Coletta","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School University of Campinas  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Salo","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School University of Campinas  Piracicaba S\u00e3o Paulo Brazil"},{"name":"Unit of Cancer Research and Translational Medicine Faculty of Medicine and Medical Research Center Oulu Oulu University Hospital University of Oulu  Oulu Finland"},{"name":"Department of Pathology Institute of Oral and Maxillofacial Disease Helsinki University Hospital University of Helsinki and HUSLAB  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.03.012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00995.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2016.09.023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12140"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12219"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-012-0335-x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.24"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.17834"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00768.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01127.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.4103\/0973-1482.147700","article-title":"Evaluation of stromal myofibroblasts in oral leukoplakia, oral submucous fibrosis, and oral squamous cell carcinoma\u2013an immunohistochemical study","volume":"11","author":"Gupta K.","year":"2015","journal-title":"Journal of Cancer Research & Therapy"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.175580"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.4103\/2278-0513.197886","article-title":"Evaluation of stromal myofibroblasts in epithelial dysplasia and oral squamous cell carcinoma: An immunohistochemical study","volume":"5","author":"Joshi P. S.","year":"2016","journal-title":"Clinical Cancer Investigation Journal"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100987"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.5005\/jp-journals-10024-1265","article-title":"Quantitative assessment of myofibroblast in severe dysplasia, microinvasion and oral squamous cell carcinoma: An immunohistochemical study","volume":"14","author":"Kapse S. C.","year":"2013","journal-title":"The Journal of Contemporary Dental Practice"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21097"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02873.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.07.001"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23627"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12142"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2004.01004.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep34314"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12493"},{"key":"e_1_2_7_26_1","first-page":"ZC14","article-title":"Evaluation of myofibroblasts by expression of alpha smooth muscle actin: A marker in fibrosis, dysplasia and carcinoma","volume":"8","author":"Rao K. B.","year":"2014","journal-title":"Journal of Clinical and Diagnostic Research: JCDR"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2763"},{"key":"e_1_2_7_28_1","article-title":"Myofibroblasts could be recruited in a chemokine (C\u2010C motif) ligand 2\u2010dependent manner in pathogenesis of oral submucous fibrosis","author":"Sarode G.","year":"2016","journal-title":"Journal of Oral Pathology and Medicine"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12208"},{"key":"e_1_2_7_30_1","first-page":"359","article-title":"Myofibroblast stromal presence and distribution in squamous epithelial carcinomas, oral dysplasia and hyperkeratosis","volume":"11","author":"Seifi S.","year":"2010","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.06.011"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01063.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100510"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12307-009-0020-0"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37004"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T06:22:57Z","timestamp":1695622977000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,26]]},"references-count":34,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/odi.12694"],"URL":"https:\/\/doi.org\/10.1111\/odi.12694","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,26]]}}}