{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:28:26Z","timestamp":1788308906294,"version":"build-2803163510"},"reference-count":99,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n                    To develop a new generation of diagnostics for halitosis, replacing the subjective organoleptic assessment, a series of exhaled breath analyzers has been developed and assessed. All three devices rely on the assessment of exhaled volatile sulfuric compounds (\n                    <jats:styled-content style=\"fixed-case\">VSC<\/jats:styled-content>\n                    s), which are mainly generated in and emitted from the oral cavity, contributing to the malodor. Portable, on\u2010site and easy to use, these devices have potential for non\u2010invasive diagnosis of halitosis. However, global assessment of exhaled\n                    <jats:styled-content style=\"fixed-case\">VSC<\/jats:styled-content>\n                    s alone has two main drawbacks: (i) the absence of VSCs does not rule out halitosis; (ii) non\u2010sulfuric volatile compounds that could be biomarkers of systemic diseases, found in up to 15% of halitosis cases, are neglected. In this article, we review and discuss progress to date in the field of oral\/exhaled volatile compounds as potential non\u2010invasive diagnostics for halitosis. We will briefly describe the generation of these compounds both from local (oral) and distal (extra\u2010oral) sources. In addition, we debate the different analytical approaches in use and discuss the potential value of bio\u2010inspired artificially intelligent olfaction in diagnosing and classifying oral and systemic diseases by analyzing exhaled breath.\n                  <\/jats:p>","DOI":"10.1111\/odi.12699","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T12:12:39Z","timestamp":1497615159000},"page":"685-695","source":"Crossref","is-referenced-by-count":60,"title":["Detection of halitosis in breath: Between the past, present, and future"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-750X","authenticated-orcid":false,"given":"MK","family":"Nakhleh","sequence":"first","affiliation":[{"name":"Univ Paris\u2010Sud Facult\u00e9 de M\u00e9decine Universit\u00e9 Paris\u2010Saclay  Le Kremlin Bic\u00eatre France"},{"name":"AP\u2010HP DHU TORINO Service de Pneumologie H\u00f4pital Bic\u00eatre  Le Kremlin Bic\u00eatre France"},{"name":"Inserm UMR_S 999 LabExLERMIT H\u00f4pital Marie Lannelongue  Le Plessis Robinson France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Quatredeniers","sequence":"additional","affiliation":[{"name":"Univ Paris\u2010Sud Facult\u00e9 de M\u00e9decine Universit\u00e9 Paris\u2010Saclay  Le Kremlin Bic\u00eatre France"},{"name":"AP\u2010HP DHU TORINO Service de Pneumologie H\u00f4pital Bic\u00eatre  Le Kremlin Bic\u00eatre France"},{"name":"Inserm UMR_S 999 LabExLERMIT H\u00f4pital Marie Lannelongue  Le Plessis Robinson France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2370-4073","authenticated-orcid":false,"given":"H","family":"Haick","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Russell Berrie Nanotechnology Institute Technion\u2013Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/10\/2\/026004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29701"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308536"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/erm.10.112"},{"key":"e_1_2_9_6_1","first-page":"96","article-title":"Chapter 7: Methodological issues of sample collection and analysis of exhaled breath","volume":"49","author":"Amann A.","year":"2010","journal-title":"European Respiratory Monograph"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.13.85"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-3961-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-595X.2002.tb00927.x"},{"key":"e_1_2_9_10_1","first-page":"174","article-title":"Diagnostic value of halitosis examination methods","volume":"37","author":"Aydin M.","year":"2016","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200900937"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12127-011-0078-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345460250040601"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345470260010901"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2012.39"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2007.04.009"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201500153"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.835"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2015.11.020"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/10\/3\/034002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1363"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0467LE"},{"key":"e_1_2_9_23_1","first-page":"97","article-title":"Characterization of volatile sulphur compounds production at individual gingival crevicular sites in humans","volume":"3","author":"Coli J. 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