{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T15:58:14Z","timestamp":1762444694610,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Objective<\/jats:title>Lichen planus has been recently associated with an increased risk of cardiovascular diseases (CVD<\/jats:styled-content>s). The oral manifestations can be divided into white hyperkeratotic lesions (WL<\/jats:styled-content>) and atrophic and erosive lesions (RL<\/jats:styled-content>). The aim of this report was to compare the presence of CVD<\/jats:styled-content>s between patients affected by WL<\/jats:styled-content> or RL<\/jats:styled-content>, to test the hypothesis that RL<\/jats:styled-content> are associated with an increased incidence of CVD<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Subjects and methods<\/jats:title>Patients were analysed through a complete collection of all the risk factors for CVD<\/jats:styled-content>s. The primary endpoint was the occurrence of a cardiovascular event\u2014acute coronary syndrome (ACS<\/jats:styled-content>), any revascularization or stroke\/TIA<\/jats:styled-content>. A multivariable logistic regression model, adjusted for age at diagnosis, body mass index, smoking, alcohol consumption, diabetes, hypertension, CVD<\/jats:styled-content>s familiarity and periodontitis, was performed.<\/jats:p><\/jats:sec>Results<\/jats:title>A prospective cohort of 307 patients has been evaluated; 185 (60.3%) had WL<\/jats:styled-content> and 122 RL<\/jats:styled-content> (39.7%). Twenty\u2010four patients had a CVD<\/jats:styled-content>. ACS<\/jats:styled-content> occurred more frequently in RL<\/jats:styled-content> (adjusted odds ratio 5.83; 95% CI<\/jats:styled-content>: 1.16\u201429.39), mainly due to the higher risk of it after the histological diagnosis of Oral lichen planus OLP<\/jats:styled-content> (odds ratio 4.23; 95% CI<\/jats:styled-content>: 0.66\u201427.23).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Patients with RL<\/jats:styled-content> could possibly have a higher risk of developing ACS<\/jats:styled-content>. Further analysis on larger cohort is however warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12700","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T11:42:44Z","timestamp":1497872564000},"page":"215-218","source":"Crossref","is-referenced-by-count":10,"title":["Can atrophic\u2010erosive oral lichen planus promote cardiovascular diseases? A population\u2010based study"],"prefix":"10.1111","volume":"24","author":[{"given":"D","family":"Conrotto","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences Oral Medicine Section CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Barattero","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Oral Medicine Section CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Carbone","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Oral Medicine Section CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Gambino","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Oral Medicine Section CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Sciannameo","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology Regional Health Service ASL TO3 Grugliasco Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Ricceri","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology Regional Health Service ASL TO3 Grugliasco Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Conrotto","sequence":"additional","affiliation":[{"name":"Division of Cardiology Citt\u00e0 della Salute e della Scienza Hospital Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Broccoletti","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Oral Medicine Section CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-7834","authenticated-orcid":false,"given":"P\u2010G","family":"Arduino","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Oral Medicine Section CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1246.1","DOI":"10.1016\/j.cjca.2015.11.016","article-title":"Does lichen planus cause increased carotid intima media thickness and impaired endothelial function?","volume":"32","author":"Aksu F.","year":"2016","journal-title":"Canadian Journal of Cardiology"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.12.025"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2012.01953.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11883-017-0652-3","article-title":"HIV infection and risk of cardiovascular diseases beyond coronary artery disease","volume":"19","author":"Barnes R. 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