{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:27:51Z","timestamp":1792686471668,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T00:00:00Z","timestamp":1501632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>The purpose of this study was to identify the patient populations at risk of medication\u2010related osteonecrosis of the jaw (<jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content>) and determine which medical and dental comorbidities are significant risk factors for this disease. An electronic search of Embase, <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, Cochrane Central Register of Controlled Trials, <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> International Clinical Trials Registry Platform and ProQuest Dissertations and Theses Global was conducted to identify all human studies that reported risk factors for <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content>. Only a qualitative analysis was performed due to significant heterogeneity in the collected data. The search strategy identified 2872 records, of which 219 studies were eligible for inclusion. A total of 4106 patients with <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> were identified, 39 different systemic diseases were implicated, and 14 medical and 11 dental risk factors were reported, although no statistical analysis of the significance of each of these factors was possible. The clinical reach of <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> may be wider than anticipated, and more data on the significance of each potential risk factor are needed to guide the identification and management of at\u2010risk patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12708","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T08:16:40Z","timestamp":1498637800000},"page":"527-536","source":"Crossref","is-referenced-by-count":211,"title":["Risk factors for medication\u2010related osteonecrosis of the jaws: A systematic review"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-6527","authenticated-orcid":false,"given":"K","family":"McGowan","sequence":"first","affiliation":[{"name":"School of Dentistry &amp; Oral Health Griffith University  Southport QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"McGowan","sequence":"additional","affiliation":[{"name":"School of Dentistry &amp; 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