{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:50:22Z","timestamp":1791888622353,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["U01 DE022939"],"award-info":[{"award-number":["U01 DE022939"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2017,11]]},"abstract":"\n Objective<\/jats:title>\n \n To examine oral complications 6\u00a0months after modern radiation therapy (\n RT<\/jats:styled-content>\n ) for head and neck cancer (\n HNC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Prospective multicenter cohort study of patients with\n HNC<\/jats:styled-content>\n receiving intensity\u2010modulated radiation therapy or more advanced\n RT<\/jats:styled-content>\n . Stimulated whole salivary flow, maximal mouth opening, oral mucositis, oral pain, oral health\u2010related quality of life (\n OH<\/jats:styled-content>\n \u2010\n QOL<\/jats:styled-content>\n ), and oral hygiene practices were measured in 372 subjects pre\u2010\n RT<\/jats:styled-content>\n and 216 subjects at 6\u00a0months from the start of\n RT<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean stimulated whole salivary flow declined from 1.09 to 0.47\u00a0ml\/min at 6\u00a0months (\n p<\/jats:italic>\n \u00a0<\u00a0.0001). Mean maximal mouth opening reduced from 45.58 to 42.53\u00a0mm at 6\u00a0months (\n p<\/jats:italic>\n \u00a0<\u00a0.0001). 8.1% of subjects had some oral mucositis at 6\u00a0months, including 3.8% with oral ulceration. Mean overall pain score was unchanged.\n OH<\/jats:styled-content>\n \u2010\n QOL<\/jats:styled-content>\n was reduced at 6\u00a0months, with changes related to dry mouth, sticky saliva, swallowing solid foods, and sense of taste (\n p<\/jats:italic>\n \u00a0\u2264\u00a0.0001). At 6\u00a0months, there was greater frequency of using dental floss and greater proportion using supplemental fluoride (\n p<\/jats:italic>\n \u00a0<\u00a0.0001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Despite advances in\n RT<\/jats:styled-content>\n techniques, patients with\n HNC<\/jats:styled-content>\n experience oral complications 6\u00a0months after\n RT<\/jats:styled-content>\n , with resulting negative impacts on oral function and quality of life.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/odi.12710","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T14:02:35Z","timestamp":1499176955000},"page":"1134-1143","source":"Crossref","is-referenced-by-count":113,"title":["Oral complications at 6\u00a0months after radiation therapy for head and neck cancer"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7662-6937","authenticated-orcid":false,"given":"RV","family":"Lalla","sequence":"first","affiliation":[{"name":"Section of Oral Medicine MC1605 University of Connecticut Health Farmington CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Treister","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine and Dentistry Brigham and Women's Hospital Boston MA USA"},{"name":"Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Sollecito","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine University of Pennsylvania School of Dental Medicine Philadelphia PA USA"},{"name":"Division of Oral Medicine University of Pennsylvania Health System Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery and Bluestone Center for Clinical Research New York University College of Dentistry New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LL","family":"Patton","sequence":"additional","affiliation":[{"name":"Department of Dental Ecology School of Dentistry University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Division of Biostatistics School of Public Health University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JS","family":"Hodges","sequence":"additional","affiliation":[{"name":"Division of Biostatistics School of Public Health University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MT","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Carolinas Medical Center Charlotte NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the OraRad Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0847-4"},{"issue":"2","key":"e_1_2_8_3_1","first-page":"91","article-title":"Post\u2010operative pain management in head and neck cancer patients: Predictive factors and efficacy of therapy","volume":"36","author":"Bianchini C.","year":"2016","journal-title":"Acta Otorhinolaryngologica Italica"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.12.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.03.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.08.010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2004.09.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813509586"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2014.04.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3337-5"},{"key":"e_1_2_8_11_1","unstructured":"European Organization for Research and Treatment of Cancer (EORTC). 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