{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:52:21Z","timestamp":1773435141214,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["1092\u20104.02\/15"],"award-info":[{"award-number":["1092\u20104.02\/15"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the association of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A G197A polymorphism and serum levels with oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) susceptibility and clinical presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Eighty\u2010three individuals diagnosed with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and 99 healthy controls (C) were consecutively recruited. All participants had desquamating oral mucosal cells collected and <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> isolated for <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A (G197A) genotyping. Blood samples of 42 <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> individuals and 23 healthy controls were collected for evaluation of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A serum levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A G197A genotypes were associated with an increased chance of having <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\u00a0\u00d7\u00a0<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OR<\/jats:styled-content>\u00a0=\u00a03.44, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.87\u20136.33, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Overall A carriers (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>) were more common in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> (38.1%) than in C (20.2%; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.43, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.53\u20133.87, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Serum levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A were higher among patients with OLP than in healthy controls (reticular, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0003; erosive, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), but no difference was found among the disease types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A G197A is associated with a higher susceptibility of developing OLP and these patients seem to present a considerable increase in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A serum levels. These findings suggest that Th17 cells, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>17A in particular, may play a pivotal role in OLP pathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12718","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T10:49:10Z","timestamp":1500979750000},"page":"377-383","source":"Crossref","is-referenced-by-count":32,"title":["<scp>IL<\/scp>17A polymorphism and elevated <scp>IL<\/scp>17A serum levels are associated with oral lichen planus"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-4318","authenticated-orcid":false,"given":"LA","family":"Gueiros","sequence":"first","affiliation":[{"name":"Centro de Ensino e Pesquisa de Laser em Odontologia \u2013 CEPLO Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Odontologia Universidade Federal de Pernambuco  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Ar\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia Oral e Patologia Faculdade de Odontologia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Souza","sequence":"additional","affiliation":[{"name":"Centro de Ensino e Pesquisa de Laser em Odontologia \u2013 CEPLO Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Odontologia Universidade Federal de Pernambuco  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CL","family":"Vieira","sequence":"additional","affiliation":[{"name":"Centro de Ensino e Pesquisa de Laser em Odontologia \u2013 CEPLO Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Odontologia Universidade Federal de Pernambuco  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RS","family":"Gomez","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia Oral e Patologia Faculdade de Odontologia Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OP","family":"Almeida","sequence":"additional","affiliation":[{"name":"\u00c1rea de Patologia Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas  Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Lodi","sequence":"additional","affiliation":[{"name":"Oral Medicine Unit Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JC","family":"Le\u00e3o","sequence":"additional","affiliation":[{"name":"Centro de Ensino e Pesquisa de Laser em Odontologia \u2013 CEPLO Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Odontologia Universidade Federal de Pernambuco  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.110137"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1540-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026229"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2011.12.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2015.1101071"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005432"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00077.x"},{"key":"e_1_2_7_9_1","article-title":"Interleukin\u201017A gene variability in patients with type 1 diabetes mellitus and chronic periodontitis: Its correlation with IL\u201017 levels and the occurrence of periodontopathic bacteria","author":"Linhartova P. 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