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The aim of this study was to explore the associations between single nucleotide polymorphisms (SNP<\/jats:styled-content>s) of miRNA<\/jats:styled-content> processing genes with the risk of non\u2010syndromic orofacial clefts (NSOC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We genotyped 12 potentially functional SNP<\/jats:styled-content>s from seven miRNA<\/jats:styled-content> processing genes (GEMIN<\/jats:styled-content>3<\/jats:italic>, DROSHA<\/jats:styled-content><\/jats:italic>, DGCR<\/jats:styled-content>8<\/jats:italic>, GEMIN<\/jats:styled-content>4<\/jats:italic>, PIWIL<\/jats:styled-content>1<\/jats:italic>, XPO<\/jats:styled-content>5,<\/jats:italic> and DICER<\/jats:styled-content><\/jats:italic>) in a case\u2013control study of 602 NSOC<\/jats:styled-content> cases and 605 controls.<\/jats:p><\/jats:sec>Results<\/jats:title>Two SNP<\/jats:styled-content>s were associated with the susceptibility of CL<\/jats:styled-content>\/P: rs10719 in DROSHA<\/jats:styled-content><\/jats:italic> led to an increased risk of cleft lip with or without palate (CL<\/jats:styled-content>\/P) (GA<\/jats:styled-content>\/AA<\/jats:styled-content>: p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.024, OR<\/jats:styled-content>\u00a0=\u00a01.33, 95% CI<\/jats:styled-content>\u00a0=\u00a0[1.04, 1.70]; GG<\/jats:styled-content>\u00a0+\u00a0GA<\/jats:styled-content>\/AA<\/jats:styled-content>: p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.037, OR<\/jats:styled-content>\u00a0=\u00a01.29, 95% CI<\/jats:styled-content>\u00a0=\u00a0[1.02, 1.63]), while rs493760 in DROSHA<\/jats:styled-content><\/jats:italic> (CC<\/jats:styled-content>\/TT<\/jats:styled-content>: p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.049, OR<\/jats:styled-content>\u00a0=\u00a00.58, 95% CI<\/jats:styled-content>\u00a0=\u00a0[0.34, 0.99]) could reduce the risk of CL<\/jats:styled-content>\/P. In addition, rs10719 (A)\u2010rs493760 (C) haplotype contributed to a decreased risk of CL<\/jats:styled-content>\/P (OR<\/jats:styled-content>\u00a0=\u00a00.77, 95% CI<\/jats:styled-content>\u00a0=\u00a0[0.63, 0.94]), whereas the rs10719 (G)\u2010rs493760 (C) haplotype contributed to the increased risk of cleft palate only (CPO<\/jats:styled-content>) (OR\u00a0=\u00a02.70, 95% CI<\/jats:styled-content>\u00a0=\u00a0[1.15, 6.35]). However, there was no difference observed in these SNP<\/jats:styled-content>s after the Bonferroni correction.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Taken together, our results provided the potential evidence that rs10719 and rs493760 might contribute to the risk of CL<\/jats:styled-content>\/P and suggested potential genetic basis and mechanisms of CL<\/jats:styled-content>\/P. The lack of association between these SNP<\/jats:styled-content>s and CPO<\/jats:styled-content> might be due to the limited sample size of CPO<\/jats:styled-content> subgroup.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12741","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T02:36:36Z","timestamp":1503282996000},"page":"422-428","source":"Crossref","is-referenced-by-count":14,"title":["Genetic variants of microRNA processing genes and risk of non\u2010syndromic orofacial clefts"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9724-9619","authenticated-orcid":false,"given":"M","family":"Xu","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Ma","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lou","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Du","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Fan","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"State Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Pan","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China"},{"name":"State Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-6866.107984"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20595"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1098119"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1590"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.1.101"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00067"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/26.1.7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03049"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00281"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7757"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm062"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gdata.2016.08.017"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.82"},{"key":"e_1_2_8_16_1","first-page":"358","article-title":"Thoughts on the etiology of clefts of the palate and lip","volume":"5","author":"Fraser F. 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