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Developmental defects of the midface caused by the absence, delays, or premature fusion of nasal and maxillary prominences vary in severity; leading to clefts, hypoplasias, and midline expansion. In the current review, we focus on the importance of the chondrocranium in craniofacial growth and how its impaired development leads to midface hypoplasia. More importantly, we reported how Matrix Gla protein (<jats:styled-content style=\"fixed-case\">MGP<\/jats:styled-content>), a potent inhibitor of extracellular matrix mineralization, facilitates midface development by preventing ectopic calcification of the nasal septum. In fact, <jats:styled-content style=\"fixed-case\">MGP<\/jats:styled-content> may act as a common link in multiple developmental pathologies all showing midface hypoplasia caused by abnormal cartilage calcification. This brief review discusses the gap in knowledge in the field, raises pertinent questions, which remain unanswered, and sheds light on the future research directions.<\/jats:p>","DOI":"10.1111\/odi.12758","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T14:30:50Z","timestamp":1519655450000},"page":"78-83","source":"Crossref","is-referenced-by-count":10,"title":["Role of Matrix Gla protein in midface development: Recent advances"],"prefix":"10.1111","volume":"24","author":[{"given":"J","family":"Marulanda","sequence":"first","affiliation":[{"name":"Faculty of Dentistry McGill University  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0156-0758","authenticated-orcid":false,"given":"M","family":"Murshed","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry McGill University  Montreal QC Canada"},{"name":"Division of Experimental Medicine Department of Medicine McGill University  Montreal QC Canada"},{"name":"Shriners Hospital for Children  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2013.01.012"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"167","article-title":"Keutel syndrome: A case report with aortic calcification","volume":"17","author":"Ayyildiz P.","year":"2012","journal-title":"F\u0131rat T\u0131p Dergisi"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2014.11.003"},{"key":"e_1_2_10_5_1","first-page":"99","article-title":"Growth of the nasal septal cartilage of the rat in vitro","volume":"144","author":"Copray J. 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