{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:58:08Z","timestamp":1776790688063,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In women with postmenopausal osteoporosis, vitamin K2 appears to decrease the incidence of hip, vertebral, and non\u2010vertebral fractures. Women with postmenopausal osteoporosis have more circulating activated T cells compared with healthy postmenopausal and premenopausal women, but the effects of vitamin K2 on T cells have not been studied. In this study, we have looked at T\u2010cell suppression by vitamin K2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Peripheral blood mononuclear cells (<jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>s) from three healthy donors were used. The <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>s were stimulated with the mitogens phytohemagglutinin and concanavalin A, and T\u2010cell proliferation was analyzed using flow cytometry based on carboxyfluorescein succinimidyl ester (<jats:styled-content style=\"fixed-case\">CSFE<\/jats:styled-content>) dye dilution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vitamin K2 (60 and 100\u00a0\u03bcM) inhibited T\u2010cell proliferation. Vitamin K1 at the same concentrations did not inhibit T\u2010cell proliferation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vitamin K2 has immunomodulatory activities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12759","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T14:30:50Z","timestamp":1519655450000},"page":"67-71","source":"Crossref","is-referenced-by-count":29,"title":["Immunomodulatory effect of vitamin K2: Implications for bone health"],"prefix":"10.1111","volume":"24","author":[{"given":"VD","family":"Myneni","sequence":"first","affiliation":[{"name":"Adult Stem Cell Section National Institute of Dental and Craniofacial Research (NIDCR) National Institutes of Health (NIH)  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5907-4691","authenticated-orcid":false,"given":"E","family":"Mezey","sequence":"additional","affiliation":[{"name":"Adult Stem Cell Section National Institute of Dental and Craniofacial Research (NIDCR) National Institutes of Health (NIH)  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0000000000000016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513001013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1997.tb01619.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","DOI":"10.3402\/fnr.v56i0.5505","article-title":"Vitamin K: Food composition and dietary intakes","volume":"56","author":"Booth S. 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