{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:14:15Z","timestamp":1793841255279,"version":"4.6.1"},"reference-count":18,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>Medication\u2010related osteonecrosis of the jaw (<jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content>) is a severe side effect of antiresorptive (bisphosphonates and denosumab) and anti\u2010angiogenic therapy used in the management of oncologic and, less frequently, osteoporotic patients. While there is good international agreement on the diagnostic and staging criteria of <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> and the cessation of antiresorptive\/anti\u2010angiogenic treatments, the gold standard of treatment is still controversial, in particular between non\u2010surgical and surgical approaches. The former usually includes antiseptic mouth rinse, cyclic antibiotic therapy, low\u2010level laser therapy and periodic dental checks; the latter consists of surgical necrotic bone removal. The purpose of this retrospective study was to describe the therapeutic approaches and outcomes of 131 lesions from 106 <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> patients treated at the Policlinic of Bari. Non\u2010surgical treatments were chosen for 24 lesions that occurred in 21 patients who, due to comorbidities and\/or the impossibility of stopping oncologic therapies, could not undergo surgical treatment. As to the outcome, all the surgically treated lesions (107) showed complete healing, with the exception of 13.5% of the lesions, all of which were stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, which did not completely heal but showed reduction to stage I. The 24 non\u2010surgically treated lesions never completely healed and, rather, generally remained stable. Only two cases exhibited a reduction in staging. Based on our observations, <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> occurring both in neoplastic and non\u2010neoplastic patients benefits more from a surgical treatment approach, whenever deemed possible, as non\u2010surgical treatments do not seem to allow complete healing of the lesions.<\/jats:p>","DOI":"10.1111\/odi.12764","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T14:30:50Z","timestamp":1519655450000},"page":"238-242","source":"Crossref","is-referenced-by-count":78,"title":["Medication\u2010related osteonecrosis of the jaw: Surgical or non\u2010surgical treatment?"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6746-7241","authenticated-orcid":false,"given":"G","family":"Favia","sequence":"first","affiliation":[{"name":"Department of Interdisciplinary Medicine Complex Operating Unit of Odontostomatology Aldo Moro University  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4506-6292","authenticated-orcid":false,"given":"A","family":"Tempesta","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine Complex Operating Unit of Odontostomatology Aldo Moro University  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5246-1253","authenticated-orcid":false,"given":"L","family":"Limongelli","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine Complex Operating Unit of Odontostomatology Aldo Moro University  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0236-0205","authenticated-orcid":false,"given":"V","family":"Crincoli","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine Complex Operating Unit of Odontostomatology Aldo Moro University  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-5338","authenticated-orcid":false,"given":"E","family":"Maiorano","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation Operating Unit of Pathological Anatomy Aldo Moro University  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.01.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.05.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"1801676","DOI":"10.1155\/2016\/1801676","article-title":"Medication\u2010related osteonecrosis of the jaws: Considerations on a new antiresorptive therapy (Denosumab) and treatment outcome after a 13\u2010year experience","volume":"2016","author":"Favia 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