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This cross\u2010sectional study examined whether <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 levels in saliva and gingival crevicular fluid (<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>) are associated with periodontitis in a Swiss population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A total of 258 subjects (107\u00a0m, 151 f, mean age: 43.5\u00a0yr; range: 21\u201358\u00a0yr) acquired from the Swiss bone marrow donor registry participated in the study. Saliva and <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> samples were collected from subjects followed by a thorough dental and periodontal examination. <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 levels were determined with immunofluorometric assay. Associations of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 levels with periodontal diagnosis, probing pocket depth (PPD) and bleeding on probing were statistically analysed with Pearson chi\u2010square test, Spearman's rho and logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 in <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> correlated with <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 in saliva (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Periodontitis was more common (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) among subjects with high levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 in saliva and\/or <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> compared with subjects with low levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108. Higher <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 levels in <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> and saliva were associated with any periodontal diagnosis (mild, moderate or severe), greater PPD, and bleeding on probing (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). When age, gender, smoking, body mass index, number of medications and decayed, missing and filled teeth were adjusted for, all observed associations remained statistically significant. The area under curve of receiver\u2010operating characteristic was 0.67 for saliva and 0.71 for <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 levels both in saliva and <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> are associated with periodontitis in a normal adult population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12769","type":"journal-article","created":{"date-parts":[[2017,9,10]],"date-time":"2017-09-10T11:32:34Z","timestamp":1505043154000},"page":"449-455","source":"Crossref","is-referenced-by-count":48,"title":["Associations of oral fluid <scp>MMP<\/scp>\u20108 with periodontitis in Swiss adult 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