{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:31:10Z","timestamp":1761744670013,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Scientific Research","award":["JP16H05546"],"award-info":[{"award-number":["JP16H05546"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>Antiresorptive agent\u2010related osteonecrosis of the jaw is a rare but significant complication in patients using antiresorptive agents such as bisphosphonates and denosumab. Although the disease is well recognized, and many studies have been performed on the management of this condition, the treatment of severe osteonecrosis is still a challenge. Most recent studies have shown an advantage of surgical treatment over conservative treatment for stage 2\/3 patients, but there is no consensus on the appropriate surgical procedures for antiresorptive agent\u2010related osteonecrosis of the jaw. Furthermore, patients with severe systemic conditions may not be appropriate for extensive surgical treatment, and the treatment protocol for such patients has not been established. In this review, issues regarding the current surgical treatment for antiresorptive agent\u2010related osteonecrosis of the jaws are discussed, with an emphasis on the clinical aspects.<\/jats:p>","DOI":"10.1111\/odi.12783","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T14:30:50Z","timestamp":1519655450000},"page":"52-56","source":"Crossref","is-referenced-by-count":9,"title":["Issues with the surgical treatment of antiresorptive agent\u2010related osteonecrosis of the jaws"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2285-2602","authenticated-orcid":false,"given":"H","family":"Kagami","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School of Dentistry Matsumoto Dental University  Shiojiri Japan"},{"name":"Department of General Medicine IMSUT Hospital The Institute of Medical Science The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School of Dentistry Matsumoto Dental University  Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School of Dentistry Matsumoto Dental University  Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology School of Dentistry Matsumoto Dental University  Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School of Dentistry Matsumoto Dental University  Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School of Dentistry Matsumoto Dental University  Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-016-0597-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-160X-7-16"},{"issue":"2","key":"e_1_2_8_4_1","first-page":"e302","article-title":"Surgical treatment vs. conservative treatment in intravenous bisphosphonate\u2010related osteonecrosis of the jaws. Systematic review","volume":"9","author":"Comas\u2010Calonge A.","year":"2017","journal-title":"Journal of Clinical and Experimental Dentistry"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2011.02.078"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2017.04.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3191"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2405"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2016.09.005"},{"issue":"7","key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.joms.2016.12.014","article-title":"Extensive surgical procedures result in better treatment outcomes for bisphosphonate\u2010related osteonecrosis of the jaw in patients with osteoporosis","volume":"775","author":"Kim H. Y.","year":"2017","journal-title":"Journal of Oral and Maxillofacial Surgery"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21380"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/298945"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.08.010"},{"issue":"9","key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic","volume":"61","author":"Marx R. E.","year":"2003","journal-title":"Journal of Maxillofacial and Oral Surgery"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90029-4"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.04.014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060285"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr435"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01568.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.5812\/traumamon.17196"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-015-0538-x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2013.07.027"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(73)90241-9"},{"issue":"4","key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.5125\/jkaoms.2017.43.4.272","article-title":"A case of bisphosphonate\u2010related osteonecrosis of the jaw with a particularly unfavourable course: A case report","volume":"43","author":"Viviano M.","year":"2017","journal-title":"Journal of the Korean Association of Oral and Maxillofacial Surgeons"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-016-0810-7"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12783","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12783","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T06:23:37Z","timestamp":1695623017000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,26]]},"references-count":25,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/odi.12783"],"URL":"https:\/\/doi.org\/10.1111\/odi.12783","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"type":"print","value":"1354-523X"},{"type":"electronic","value":"1601-0825"}],"subject":[],"published":{"date-parts":[[2018,2,26]]}}}