{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:06:15Z","timestamp":1768734375391,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H02578"],"award-info":[{"award-number":["15H02578"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K15763"],"award-info":[{"award-number":["15K15763"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Besides inflammatory bone loss, trauma from occlusion (<jats:styled-content style=\"fixed-case\">TO<\/jats:styled-content>)\u2010induced alveolar bone loss increases the risk of future tooth loss. We have shown that resveratrol, a polyphenol, possesses anti\u2010inflammatory characteristics and a suppressive effect on osteoclastogenesis. Therefore, we investigated the effects of resveratrol on <jats:styled-content style=\"fixed-case\">TO<\/jats:styled-content>\u2010induced bone loss in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Trauma from occlusion was induced by overlaying composite resin onto the maxillary first molar of C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice. <jats:styled-content style=\"fixed-case\">TO<\/jats:styled-content>\u2010induced mice were administered either resveratrol or vehicle for 15\u00a0days from 5\u00a0days before <jats:styled-content style=\"fixed-case\">TO<\/jats:styled-content> induction. The mice administered vehicle only served as controls. The effect of resveratrol on bone resorption was assessed histologically. Gene expression in gingival and periodontal ligament tissues was analyzed. In vitro effect of resveratrol on the differentiation of <jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content> 264.7 cells and bone marrow\u2010derived macrophages into osteoclastic cells was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Resveratrol administration significantly decreased the bone loss and suppressed the elevated expression of osteoclastogenesis\u2010related gene in periodontal ligament tissue by <jats:styled-content style=\"fixed-case\">TO<\/jats:styled-content>. Resveratrol treatment also suppressed the differentiation of both <jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content> 264.7 cells and bone marrow\u2010derived macrophages into osteoclastic cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Resveratrol administration suppressed the <jats:styled-content style=\"fixed-case\">TO<\/jats:styled-content>\u2010induced alveolar bone loss by suppressing osteoclast differentiation, suggesting that resveratrol is effective in preventing both inflammation and mechanical stress\u2010induced alveolar bone resorption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12785","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T08:02:50Z","timestamp":1506326570000},"page":"412-421","source":"Crossref","is-referenced-by-count":24,"title":["Resveratrol suppresses the alveolar bone resorption induced by artificial trauma from occlusion in mice"],"prefix":"10.1111","volume":"24","author":[{"given":"Y","family":"Matsuda","sequence":"first","affiliation":[{"name":"Research Unit for Oral\u2010Systemic Connection Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"},{"name":"Division of Oral Science for Health Promotion Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"},{"name":"Division of Periodontology Department of Oral Biological Science Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Minagawa","sequence":"additional","affiliation":[{"name":"Research Unit for Oral\u2010Systemic Connection Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"},{"name":"Division of Periodontology Department of Oral Biological Science Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Okui","sequence":"additional","affiliation":[{"name":"Research Unit for Oral\u2010Systemic Connection Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"},{"name":"Division of Periodontology Department of Oral Biological Science Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1893-4202","authenticated-orcid":false,"given":"K","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Research Unit for Oral\u2010Systemic Connection Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"},{"name":"Division of Oral Science for Health Promotion Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9728.2004.00097.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2007.03.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12091"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4801245a"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00110.2004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb02111.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1961.32.4.290"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.1.98"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.09.053"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4049\/jimmunol.163.1.434","article-title":"Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function","volume":"163","author":"Jimi E.","year":"1999","journal-title":"Journal of Immunology"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00446.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.2.210"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2842.2000.00542.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.013"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00673-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020240"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2012.07.006"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12238"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.10.004"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1542-0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.8.902"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.2.249"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110514"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.06.011"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0011-8532(22)02849-X","article-title":"Occlusion and periodontal disease","volume":"24","author":"Polson A. M.","year":"1980","journal-title":"Dental Clinics of North America"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0975"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R109.041087"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1981.52.9.511"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.06.004"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(91)70005-H"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.05.003"},{"key":"e_1_2_7_33_1","first-page":"269","article-title":"Experimental tooth hypermobility in the dog. A methodological study","volume":"24","author":"Svanberg G.","year":"1973","journal-title":"Odontol Revy"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0252"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.10.002"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12232"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01179.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.00960.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.09.015"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fodi.12785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.12785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T23:38:09Z","timestamp":1695685089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.12785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,23]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/odi.12785"],"URL":"https:\/\/doi.org\/10.1111\/odi.12785","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,23]]}}}