{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:37Z","timestamp":1740124357124,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Objective<\/jats:title>To investigate the presence of eosinophils in oral intraepithelial neoplasia (OIN<\/jats:styled-content>) and oral squamous cell carcinoma (OSCC<\/jats:styled-content>) lesions and its relation to invasion.<\/jats:p><\/jats:sec>Subjects and methods<\/jats:title>Ninety\u2010nine oral biopsies were selected and subdivided into the following: OIN<\/jats:styled-content>\u20101(16 cases), OIN<\/jats:styled-content>\u20102 (18 cases), OIN<\/jats:styled-content>\u20103 (17 cases), microinvasive OSCC<\/jats:styled-content> (10 cases), non\u2010metastatic OSCC<\/jats:styled-content> (22 cases) and metastatic OSCC<\/jats:styled-content> (16 cases). The tissue eosinophilia was evaluated histologically in slices stained with haematoxylin and eosin.<\/jats:p><\/jats:sec>Results<\/jats:title>Eosinophil distribution was associated with diagnosis severity (p<\/jats:italic>\u00a0<\u00a0.01). A significant difference was found between OIN<\/jats:styled-content>\u20103 or microinvasive OSCC<\/jats:styled-content> and non\u2010metastatic or metastatic OSCC<\/jats:styled-content>. Stromal invasion threshold was 7 eos\/10 high power field (hpf) (96.1% specificity and 62.5% sensitivity). Eosinophils were absent in OIN<\/jats:styled-content>\u20101; in OIN<\/jats:styled-content>\u20102, two cases were positive. In OIN<\/jats:styled-content>\u20103, five cases showed tissue eosinophilia, four of which had \u22653 eos\/hpf or \u22657 eos\/10 hpf. Three cases were suspected of invasion; two had a previous history of OSCC<\/jats:styled-content> with elevated eosinophil infiltrate. In microinvasive OSCC<\/jats:styled-content>, the four positive cases presented \u22653 eos\/hpf and \u22657 eos\/10 hpf. Although not significantly different, non\u2010metastatic invasive OSCC<\/jats:styled-content> had a higher number of cases (68.2%) with \u226522 eos\/10 hpf contrasting with 50% in metastatic OSCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our results suggest that eosinophils can be considered an indicator of invasion in OIN<\/jats:styled-content>, helping in cases of difficult diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12789","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T14:30:50Z","timestamp":1519655450000},"page":"103-108","source":"Crossref","is-referenced-by-count":2,"title":["Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion"],"prefix":"10.1111","volume":"24","author":[{"given":"CP","family":"Martinelli\u2010Kl\u00e4y","sequence":"first","affiliation":[{"name":"Oral Medicine and Oral and Maxillofacial Pathology Unit Laboratory of Oral & Maxillofacial Pathology Division of Oral Maxillofacial Surgery Department of Surgery University Hospitals of Geneva University of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9347-3736","authenticated-orcid":false,"given":"T","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Oral Medicine and Oral and Maxillofacial Pathology Unit Laboratory of Oral & Maxillofacial Pathology Division of Oral Maxillofacial Surgery Department of Surgery University Hospitals of Geneva University of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRRN","family":"Mendis","sequence":"additional","affiliation":[{"name":"Oral Medicine and Oral and Maxillofacial Pathology Unit Laboratory of Oral & Maxillofacial Pathology Division of Oral Maxillofacial Surgery Department of Surgery University Hospitals of Geneva University of Geneva Geneva 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