{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:15:00Z","timestamp":1780474500781,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study evaluated low\u2010intensity pulsed ultrasound effects for temporomandibular joint osteoarthritis in adult rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Osteoarthritis\u2010like lesions were induced in 24 adult rats\u2019 temporomandibular joints with low\u2010dose mono\u2010iodoacetate injections. The rats were divided into four groups: control and mono\u2010iodoacetate groups, injected with contrast media and mono\u2010iodoacetate, respectively, at 12\u00a0weeks and observed until 20\u00a0weeks; and low\u2010intensity pulsed ultrasound and mono\u2010iodoacetate + low\u2010intensity pulsed ultrasound groups, injected with contrast media and mono\u2010iodoacetate, respectively, at 12\u00a0weeks with low\u2010intensity pulsed ultrasound performed from 16 to 20\u00a0weeks. Condylar bone mineral density, bone mineral content and bone volume were evaluated weekly with microcomputed tomography. Histological and immunohistochemical staining for matrix metalloproteinases\u201013 was performed at 20\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 20\u00a0weeks, the mono\u2010iodoacetate + low\u2010intensity pulsed ultrasound group showed significantly higher bone mineral density, bone mineral content and bone volume than the mono\u2010iodoacetate group; however, these values remained lower than those in the other two groups. On histological and immunohistochemical analysis, the chondrocytes were increased, and fewer matrix metalloproteinases\u201013 immunopositive cells were identified in the mono\u2010iodoacetate + low\u2010intensity pulsed ultrasound group than mono\u2010iodoacetate group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low\u2010intensity pulsed ultrasound for 2\u00a0weeks may have therapeutic potential for treating temporomandibular joint osteoarthritis lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12798","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T17:49:20Z","timestamp":1508953760000},"page":"600-610","source":"Crossref","is-referenced-by-count":10,"title":["Low\u2010intensity pulsed ultrasound stimulation for mandibular condyle osteoarthritis lesions in rats"],"prefix":"10.1111","volume":"24","author":[{"given":"A","family":"Kanaguchi Arita","sequence":"first","affiliation":[{"name":"Department of Orthodontic Science Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0220-742X","authenticated-orcid":false,"given":"I","family":"Yonemitsu","sequence":"additional","affiliation":[{"name":"Department of Orthodontic Science Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Orthodontic Science Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Orthodontic Science Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Orthodontic Science Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.4.671"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4236\/ojrm.2013.21002","article-title":"Effects of low intensity pulsed ultrasound stimulation on bone regeneration in rat parietal bone defect model","volume":"2","author":"Chen K.","year":"2013","journal-title":"Open Journal of Regenerative Medicine"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2012.08.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2006.05.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.091012"},{"key":"e_1_2_8_7_1","first-page":"631","article-title":"Growth modification of the rabbit mandible using therapeutic ultrasound: Is it possible to enhance functional appliance results?","volume":"73","author":"El\u2010Bialy T.","year":"2003","journal-title":"The Angle Orthodontist"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.05.011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2011.03.035"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bonekey.2014.119"},{"key":"e_1_2_8_11_1","article-title":"The relationship between osteoporosis and osteoarthritis of the knee: A report of 2 cases with suspected osteonecrosis","volume":"514058","author":"Horikawa A.","year":"2014","journal-title":"Case Reports in Orthopedics"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2014.08.010"},{"key":"e_1_2_8_13_1","first-page":"S444","article-title":"Global transcriptome analysis in osteoarthritic cartilage reveals significant differential gene expression and associations with histologic disease progression","volume":"66","author":"Jeffries M. 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