{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T21:27:12Z","timestamp":1753738032952,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560440"],"award-info":[{"award-number":["81560440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Objective<\/jats:title>The purpose of this study was to investigate the clinical and histopathological characteristics of GLUT<\/jats:styled-content>1 in human tongue squamous cell carcinoma (TSCC<\/jats:styled-content>) and the role of plumbagin (PLB<\/jats:styled-content>)\u2010mediating GLUT<\/jats:styled-content>1 in the growth of TSCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Subjects and methods<\/jats:title>Forty\u2010five cases of TSCC<\/jats:styled-content> samples were collected and the expression and location of GLUT<\/jats:styled-content>1 was analyzed. The role and mechanism of PLB<\/jats:styled-content> meditating GLUT<\/jats:styled-content>1 in the inhibitory growth of human TSCC<\/jats:styled-content> cell line CAL<\/jats:styled-content>27 were investigated in vitro<\/jats:italic> and vivo<\/jats:italic>.<\/jats:p><\/jats:sec>Results<\/jats:title>The expression of GLUT<\/jats:styled-content>1 was observed in all samples of human TSCC<\/jats:styled-content> by immunohistochemical staining. GLUT<\/jats:styled-content>1 expression was significantly correlated with lymph node metastasis and clinical stage in TSCC<\/jats:styled-content>. PLB<\/jats:styled-content> treatment decreased cell viability and colony formation, and increased cell apoptosis in association with the downregulation of GLUT<\/jats:styled-content>1 via inhibiting PI<\/jats:styled-content>3K\/Akt pathway in vitro<\/jats:italic> and PLB<\/jats:styled-content> suppressed tumor growth in correlation with downregulation of GLUT<\/jats:styled-content>1, compared with control group in vivo.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The findings demonstrated a novel anti\u2010cancer mechanism of PLB<\/jats:styled-content>, inhibitory TSCC<\/jats:styled-content> growth via suppressing PI<\/jats:styled-content>3K\/Akt\/GLUT<\/jats:styled-content>1 pathway, which will supply a theoretical basis for PLB<\/jats:styled-content> to treat TSCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12799","type":"journal-article","created":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T14:56:36Z","timestamp":1509202596000},"page":"920-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Plumbagin\u2010mediating GLUT<\/scp>1 suppresses the growth of human tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-4451","authenticated-orcid":false,"given":"S","family":"Na","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Nanchang University Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Nanchang University Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Nanchang University Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Nanchang University Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Huang","sequence":"additional","affiliation":[{"name":"Research Institute of Digestive Diseases and Department of Gastroenterology The First Affiliated Hospital of Nanchang University Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"Xu","sequence":"additional","affiliation":[{"name":"Research Institute of Digestive Diseases and Department of Gastroenterology The First Affiliated Hospital of Nanchang University Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Nanchang University Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-3685","authenticated-orcid":false,"given":"J","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Nanchang University Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0256-4947.75771"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2007.39.3.109"},{"key":"e_1_2_8_4_1","first-page":"1381","article-title":"Expression of Glut\u20101 is a prognostic marker for oral squamous cell carcinoma patients","volume":"20","author":"Eckert AW","year":"1994","journal-title":"Oncology Reports"},{"key":"e_1_2_8_5_1","first-page":"1835","article-title":"Intracellular ATP levels determine cell death fate by apoptosis or necrosis","volume":"57","author":"Eguchi Y.","year":"1997","journal-title":"Cancer Research"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.313"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1457"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.18632\/oncotarget.6748","article-title":"Negative regulation of Bmi\u20101 by AMPK and implication in cancer progression","volume":"7","author":"Huang D. 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