{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:51:43Z","timestamp":1790711503463,"version":"4.1.0"},"reference-count":108,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["FONDAP 15130011"],"award-info":[{"award-number":["FONDAP 15130011"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008736","name":"Fondo de Fomento al Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1140907"],"award-info":[{"award-number":["1140907"]}],"id":[{"id":"10.13039\/501100008736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Wounds in the oral mucosa heal faster and more efficiently than those in the skin, although the mechanisms underlying these differences are not completely clear. In the last 10\u00a0years, a group of salivary peptides, the histatins, has gained attention on behalf of their ability to improve several phases of the wound\u2010healing process. In addition to their roles as anti\u2010microbial agents and in enamel maintenance, histatins elicit other biological effects, namely by promoting the migration of different cell types contained in the oral mucosa and in non\u2010oral tissues. Histatins, and specifically histatin\u20101, promote cell adhesion and migration in oral keratinocytes, gingival and dermal fibroblasts, non\u2010oral epithelial cells, and endothelial cells. This is particularly relevant, as histatin\u20101 promotes the re\u2010epithelialization phase and the angiogenic responses by increasing epithelial and endothelial cell migration. Although the molecular mechanisms associated with histatin\u2010dependent cell migration remain poorly understood, recent studies have pointed to the control of signaling endosomes and the balance of small <jats:styled-content style=\"fixed-case\">GTP<\/jats:styled-content>ases. This review aimed to update the literature on the effects of histatins in cell migration, with a focus on wound healing. We will also discuss the consequences that this increasing field will have in disease and therapy design.<\/jats:p>","DOI":"10.1111\/odi.12816","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T07:57:04Z","timestamp":1513065424000},"page":"1150-1160","source":"Crossref","is-referenced-by-count":85,"title":["Histatins, wound healing, and cell migration"],"prefix":"10.1111","volume":"24","author":[{"given":"P","family":"Torres","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Institute for Research in Dental Sciences Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Castro","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Institute for Research in Dental Sciences Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Reyes","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Institute for Research in Dental Sciences Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5973-7248","authenticated-orcid":false,"given":"VA","family":"Torres","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Institute for Research in Dental Sciences Universidad de Chile  Santiago Chile"},{"name":"Advanced Center for Chronic Diseases (ACCDiS) Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540405200307"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2016.1214966"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.176.4035.673"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.850766"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(76)90455-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/759731"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(95)00036-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152613"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12380"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358784"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00003-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.11.010"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1076\/brhm.33.2.213.1314"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404322200"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010503"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.03.037"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1993.1304"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(65)90005-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2010.03.001"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111661"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.141689"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740120601"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.12.1193"},{"key":"e_1_2_7_25_1","first-page":"217","article-title":"The role of saliva in oral health and the causes and effects of xerostomia","volume":"58","author":"Epstein J. 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