{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:19:41Z","timestamp":1780377581685,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To perform a randomized, placebo\u2010controlled, double\u2010blind study, with a follow\u2010up period of 6\u00a0months, for the use of topical clobetasol in cases of symptomatic oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Thirty\u2010two participants were analyzed, with the aims of: (I) to compare the usefulness of topically applied clobetasol propionate 0.05% (mixed with 4% hydroxyethyl cellulose gel) and 4% hydroxyethyl cellulose gel alone (considered as placebo) in the management of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>; (<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) to describe which of them is quicker in decreasing signs and reported symptoms, and (<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>) which is able to give the proper longer remission in the follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Symptoms improved in all clobetasol\u2010treated patients during the first 2\u00a0months of therapy, while only 50% of placebo control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.005) displayed similar results; of the remaining half, 12.5% did experienced a worsening while 37.5% remained stable. Regarding clinical signs, 87.5% of clobetasol\u2010treated patients improved, while only 62.5% of the placebo\u2010treated patients had a positive response (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.229).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is possible to report that clobetasol, at this dosage, has been more effective than a placebo at provoking symptoms improvement in subjects affected by atrophic\u2010erosive oral lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12821","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T11:43:16Z","timestamp":1514979796000},"page":"772-777","source":"Crossref","is-referenced-by-count":29,"title":["Randomized, placebo\u2010controlled, double\u2010blind trial of clobetasol propionate 0.05% in the treatment of oral lichen 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