{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:33:45Z","timestamp":1791855225844,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,7]]},"abstract":"\n Objective<\/jats:title>\n \n We aimed to characterize proliferative verrucous leukoplakia (\n PVL<\/jats:styled-content>\n ) from a clinical and histopathological standpoint and suggest an updated classification.\n <\/jats:p>\n <\/jats:sec>\n \n Subjects and Methods<\/jats:title>\n \n Records of patients seen at three oral medicine centers with a clinical diagnosis of\n PVL<\/jats:styled-content>\n were reviewed for clinical and histopathological features and malignant transformation (\n MT<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were 42 patients (median age: 69\u00a0years [range: 36\u201388]; 35 females). 12.2% were current smokers. Family history of cancer was present in 43.7% of patients. Partial demarcation of lesion margins was present in 31.3% of lesions, followed by verrucous (27.5%), smooth (22.7%) erythematous (22.3%), and fissured (18.3%) appearance. Large and contiguous and multisite and non\u2010contiguous lesions comprised 57.1% (24\/42) and 35.7% (15\/42) of\n PVL<\/jats:styled-content>\n cases, respectively. 19.1% had prominent erythema (erythroleukoplakia). The most common histopathological diagnosis at first visit was hyperkeratosis without dysplasia (22\/42; 56.4%).\n MT<\/jats:styled-content>\n occurred in 71.4% patients after a median of 37\u00a0months [range: 1\u2013210] from initial visit; erythroleukoplakia exhibited\n MT<\/jats:styled-content>\n in 100% of cases.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The generic term \u201cproliferative leukoplakia (\n PL<\/jats:styled-content>\n )\u201d may be more appropriate than\n PVL<\/jats:styled-content>\n because 18.3% were fissured and 22.7% erythematous. We also propose the term proliferative erythroleukoplakia to more accurately describe the subset of\n PL<\/jats:styled-content>\n with prominent erythema, which had the highest\n MT<\/jats:styled-content>\n rate.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/odi.12830","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T11:06:29Z","timestamp":1516100789000},"page":"749-760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["Proliferative leukoplakia: Proposed new clinical diagnostic criteria"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-6000","authenticated-orcid":false,"given":"A","family":"Villa","sequence":"first","affiliation":[{"name":"Division of Oral Medicine and Dentistry Brigham and Women's Hospital and Dana Farber Cancer Institute Boston MA USA"},{"name":"Department of Oral Medicine Infection and Immunity Harvard School of Dental Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RS","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Infection and Immunity Harvard School of Dental Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AR","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Pathology, Radiology and Medicine New York University College of Dentistry New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3372-1536","authenticated-orcid":false,"given":"F","family":"De Abreu Alves","sequence":"additional","affiliation":[{"name":"Stomatology Department at AC Camargo Cancer Center Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Guollo","sequence":"additional","affiliation":[{"name":"Stomatology Department at AC Camargo Cancer Center Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Ojeda","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Dentistry School of Dentistry UT Health San Antonio San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SB","family":"Woo","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine and Dentistry Brigham and Women's Hospital and Dana Farber Cancer Institute Boston MA USA"},{"name":"Department of Oral Medicine Infection and Immunity Harvard School of Dental Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815586779"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.10.023"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00167.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.05.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01632.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24845"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00506.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2004.02.007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.15.e839"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.02.014"},{"key":"e_1_2_7_12_1","first-page":"E118","article-title":"Oral lichenoid disease as a premalignant condition: The controversies and the unknown","volume":"14","author":"Cortes-Ramirez D. 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