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Proper selection of a cell source is important for the desired application. This review describes the discovery and usefulness of dedifferentiated fat (<jats:styled-content style=\"fixed-case\">DFAT<\/jats:styled-content>) cells as a cell source for tissue engineering. Dedifferentiated Fat cells are a highly homogeneous cell population (high purity), highly proliferative, and possess a multilineage potential for differentiation into various cell types under proper in vitro inducing conditions and in vivo. Moreover, <jats:styled-content style=\"fixed-case\">DFAT<\/jats:styled-content> cells have a higher differentiation capability of becoming osteoblasts, chondrocytes, and adipocytes than do bone marrow\u2010derived mesenchymal stem cells and\/or adipose tissue\u2010derived stem cells. The usefulness of <jats:styled-content style=\"fixed-case\">DFAT<\/jats:styled-content> cells in vivo for periodontal tissue, bone, peripheral nerve, muscle, cartilage, and fat tissue regeneration was reported. Dedifferentiated Fat cells obtained from the human buccal fat pad (<jats:styled-content style=\"fixed-case\">BFP<\/jats:styled-content>) are a minimally invasive procedure with limited esthetic complications for patients. The <jats:styled-content style=\"fixed-case\">BFP<\/jats:styled-content> is a convenient and accessible anatomical site to harvest <jats:styled-content style=\"fixed-case\">DFAT<\/jats:styled-content> cells for dentists and oral surgeons, and thus is a promising cell source for oral and maxillofacial tissue engineering.<\/jats:p>","DOI":"10.1111\/odi.12832","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T14:57:35Z","timestamp":1516633055000},"page":"1161-1167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Dedifferentiated Fat (<scp>DFAT<\/scp>) cells: A cell source for oral and maxillofacial tissue engineering"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8716-5056","authenticated-orcid":false,"given":"N","family":"Kishimoto","sequence":"first","affiliation":[{"name":"Craniofacial Tissue Engineering and Stem Cells Laboratory Faculty 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