{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:30:31Z","timestamp":1788949831813,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/11020\u20105"],"award-info":[{"award-number":["2014\/11020\u20105"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/11806\u20107"],"award-info":[{"award-number":["2017\/11806\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Oral lichen planus is a chronic, T\u2010cell\u2010mediated, inflammatory disease that affects the oral cavity. The oral lichen planus pathogenesis is still unclear, however, the main evidence is that the mechanisms of activation of different T lymphocyte pathway induce apoptosis with an increase in Th1 and Th17 subtypes cells, triggered by the release of cytokines. This study analysed saliva proteomics to identify protein markers that might be involved in the pathogenesis and development of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Proteins differentially expressed by oral lichen planus and healthy controls were screened using mass spectrometry; the proteins found in oral lichen planus were subjected to bioinformatics analysis, including gene ontology and string networks analysis. The multiplex analysis validation allowed the correlation between the proteins identified and the involved cytokines in Th17 response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and eight proteins were identified in oral lichen planus, of which 17 proteins showed a high interaction between them and indicated an association with the disease. Expression of these proteins was correlated with the triggering of cytokines, more specifically the Th17 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Proteins, such as S100A8, S100A9, haptoglobin, can trigger cytokines and might be associated with a pathological function and antioxidant activities in oral lichen planus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12837","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T02:12:36Z","timestamp":1517364756000},"page":"784-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Salivary proteomics in lichen planus: A relationship with pathogenesis?"],"prefix":"10.1111","volume":"24","author":[{"given":"MM","family":"Souza","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5328-0937","authenticated-orcid":false,"given":"GP","family":"Florezi","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MMS","family":"Nico","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"de Paula","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FM","family":"Paula","sequence":"additional","affiliation":[{"name":"Medical Investigation Laboratory Hospital das Cl\u00ednicas School of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SV","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.tripleo.2006.11.001","article-title":"Oral lichen planus and oral lichenoid lesions: Diagnostic and therapeutic considerations","volume":"103","author":"Al\u2010Hashimi I.","year":"2007","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3356"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"3","article-title":"Oxidative stress in lichen planus","volume":"19","author":"Aly D. 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