{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:50:35Z","timestamp":1780462235586,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T00:00:00Z","timestamp":1528329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of preventive dental management on reducing the incidence and delaying the onset of bisphosphonate\u2010related osteonecrosis of the jaw (<jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>) in patients treated with intravenous zoledronic acid (<jats:styled-content style=\"fixed-case\">ZA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This single\u2010center clinical study included 255 patients with cancer monitored over a 6\u2010year period. Patients received dental treatment prior to (group A) or after (group B) the initiation of <jats:styled-content style=\"fixed-case\">ZA<\/jats:styled-content> therapy. Dental treatments performed, incidence proportion (<jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>), and incidence rate (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) in both groups were analyzed using significance tests. <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content> onset was estimated using the Kaplan\u2013Meier estimator and log\u2010rank test. Independent risk factors to develop <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content> were evaluated using Cox regression analysis models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven patients suffered from <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u00a0=\u00a014.5%), 7.3% in group A and 36.5% in group B (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.000). The <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> was 0.007 patients\/month in group B and 0.004 in group A. <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>\u2010free survival at 3\u00a0years was 97% in group A and 66% in group B. Survival curves were significant (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.056) according to log\u2010rank test. Multivariate Cox models showed that dental extractions (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.000) were significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content> occurred significantly in patients who underwent dental extractions after the initiation of <jats:styled-content style=\"fixed-case\">ZA<\/jats:styled-content> and did not accomplish a preventive dental program.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.12842","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T14:53:02Z","timestamp":1518015182000},"page":"1029-1036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Preventive dental management of osteonecrosis of the jaws related to zoledronic acid treatment"],"prefix":"10.1111","volume":"24","author":[{"given":"JA","family":"Coello\u2010Suanzes","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Virgen Macarena University Hospital  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Rollon\u2010Ugalde","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Virgen Macarena University Hospital  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Casta\u00f1o\u2010Seiquer","sequence":"additional","affiliation":[{"name":"Department of Preventive and Community Dentistry Faculty of Dentistry University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Lledo\u2010Villar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Virgen Macarena University Hospital  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Herce\u2010Lopez","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Virgen Macarena University Hospital  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2770-8573","authenticated-orcid":false,"given":"P","family":"Infante\u2010Cossio","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Rollon\u2010Mayordomo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Virgen Macarena University Hospital  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.11.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.01.002"},{"key":"e_1_2_8_4_1","first-page":"CD012432","article-title":"Interventions for managing medication\u2010related osteonecrosis of the jaw","volume":"10","author":"Beth\u2010Tasdogan N. 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